B-cell chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease whose outcome can be foreseen by investigating the mutational status of immunoglobulin heavy chain variable (IGHV) genes. Moreover, a different prognosis was reported for CLL expressing specific IGHV genes in the context or not of stereotyped B-cell receptors. Here we investigated novel associations between usage of specific IGHV genes and clinical features in CLL.

Bomben, R., Dal Bo, M., Benedetti, D., Capello, D., Forconi, F., Marconi, D., et al. (2010). Expression of mutated IGHV3-23 genes in chronic lymphocytic leukemia identifies a disease subset with peculiar clinical and biological features. CLINICAL CANCER RESEARCH, 16(2), 620-628 [10.1158/1078-0432.CCR-09-1638].

Expression of mutated IGHV3-23 genes in chronic lymphocytic leukemia identifies a disease subset with peculiar clinical and biological features

DEL PRINCIPE, MARIA ILARIA;DEL POETA, GIOVANNI;
2010-01-15

Abstract

B-cell chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease whose outcome can be foreseen by investigating the mutational status of immunoglobulin heavy chain variable (IGHV) genes. Moreover, a different prognosis was reported for CLL expressing specific IGHV genes in the context or not of stereotyped B-cell receptors. Here we investigated novel associations between usage of specific IGHV genes and clinical features in CLL.
15-gen-2010
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/15 - MALATTIE DEL SANGUE
English
Con Impact Factor ISI
Mutant Proteins; Diagnosis, Differential; MicroRNAs; Neoplasm Staging; Humans; Prognosis; Aged; Gene Rearrangement; Gene Expression Regulation, Leukemic; Gene Expression Profiling; Aged, 80 and over; Leukemia, Lymphocytic, Chronic, B-Cell; Adult; Cohort Studies; Middle Aged; Genes, Immunoglobulin Heavy Chain
Bomben, R., Dal Bo, M., Benedetti, D., Capello, D., Forconi, F., Marconi, D., et al. (2010). Expression of mutated IGHV3-23 genes in chronic lymphocytic leukemia identifies a disease subset with peculiar clinical and biological features. CLINICAL CANCER RESEARCH, 16(2), 620-628 [10.1158/1078-0432.CCR-09-1638].
Bomben, R; Dal Bo, M; Benedetti, D; Capello, D; Forconi, F; Marconi, D; Bertoni, F; Maffei, R; Laurenti, L; Rossi, D; DEL PRINCIPE, Mi; Luciano, F; Sozzi, E; Cattarossi, I; Zucchetto, A; Rossi, F; Bulian, P; Zucca, E; Nicoloso, M; Degan, M; Marasca, R; Efremov, D; DEL POETA, G; Gaidano, G; Gattei, V
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/40799
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