We measured α-Klotho in CSF and serum of PD patients at early stage of the disease, finding two distinct pools, the first increased, the second reduced. CSF α-Klotho was inversely associated with CSF α-synuclein levels. Our preliminary results suggest α-Klotho as potential biomarker or therapeutic target in PD.

Sancesario, G.m., Di Lazzaro, G., Grillo, P., Biticchi, B., Giannella, E., Alwardat, M., et al. (2021). Biofluids profile of ?-Klotho in patients with Parkinson{'}s disease. PARKINSONISM & RELATED DISORDERS, 90, 62-64 [10.1016/j.parkreldis.2021.08.004].

Biofluids profile of ?-Klotho in patients with Parkinson{'}s disease

Di Lazzaro, G.;Grillo, P.;Pieri, M.;Bernardini, S.;Mercuri, N. B.;Pisani, A.;Schirinzi, T.
2021-01-01

Abstract

We measured α-Klotho in CSF and serum of PD patients at early stage of the disease, finding two distinct pools, the first increased, the second reduced. CSF α-Klotho was inversely associated with CSF α-synuclein levels. Our preliminary results suggest α-Klotho as potential biomarker or therapeutic target in PD.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIOS-09/A - Biochimica clinica e biologia molecolare clinica
English
Biomarkers
Blood
CSF
Parkinson's disease
α-Klotho
Sancesario, G.m., Di Lazzaro, G., Grillo, P., Biticchi, B., Giannella, E., Alwardat, M., et al. (2021). Biofluids profile of ?-Klotho in patients with Parkinson{'}s disease. PARKINSONISM & RELATED DISORDERS, 90, 62-64 [10.1016/j.parkreldis.2021.08.004].
Sancesario, Gm; Di Lazzaro, G; Grillo, P; Biticchi, B; Giannella, E; Alwardat, M; Pieri, M; Bernardini, S; Mercuri, Nb; Pisani, A; Schirinzi, T...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/407583
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