Oligodendrocytes make myelin in the vertebrate central nervous system (CNS). They develop from oligodendrocyte precursor cells (OPCs), most of which divide a limited number of times before they stop and differentiate. OPCs can be purified from the developing rat optic nerve and stimulated to proliferate in serum-free culture by PDGF. They can be induced to differentiate in vitro by either thyroid hormone (TH) or PDGF withdrawal. It was shown previously that a dominant-negative form of p53 could inhibit OPC differentiation induced by TH but not by PDGF withdrawal, suggesting that the p53 family of proteins might play a part in TH-induced differentiation. As the dominant-negative p53 used inhibited all three known p53 family members - p53, p63 and p73 - it was uncertain which family members are important for this process. Here, we provide evidence that both p53 and p73, but not p63, are involved in TH-induced OPC differentiation and that p73 also plays a crucial part in PDGF-withdrawal-induced differentiation. This is the first evidence for a role of p73 in the differentiation of a normal mammalian cell.
Billon N., T.A. (2004). Roles for p53 and p73 during oligodendrocyte development. DEVELOPMENT, 131(6), 1211-1220 [10.1242/dev.01035].
|Tipologia:||Articolo su rivista|
|Citazione:||Billon N., T.A. (2004). Roles for p53 and p73 during oligodendrocyte development. DEVELOPMENT, 131(6), 1211-1220 [10.1242/dev.01035].|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore BIO/11|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1242/dev.01035|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2004|
|Titolo:||Roles for p53 and p73 during oligodendrocyte development|
|Autori:||Billon N., Terrinoni A., Jolicoeur C., McCarthy A., Richardson W.D., Melino G., Raff M.|
|Appare nelle tipologie:||01 - Articolo su rivista|