The proto-oncogene c-KIT encodes a tyrosine kinase receptor essential during embryonic development and postnatal life. Although deregulated expression of c-KIT has been reported, its role in colorectal carcinoma remains controversial: some authors have described a correlation between c-KIT expression and colorectal cancer (CRC), while others have failed to detect the receptor in the majority of neoplasia examined. To address this question, we designed a prospective study to analyze the expression of c-KIT in normal and neoplastic colonic mucosa of the same patient.

Sammarco, I., Capurso, G., Coppola, L., Bonifazi, A., Cassetta, S., Delle Fave, G., et al. (2004). Expression of the proto-oncogene c-KIT in normal and tumor tissues from colorectal carcinoma patients. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 19(6), 545-553 [10.1007/s00384-004-0601-9].

Expression of the proto-oncogene c-KIT in normal and tumor tissues from colorectal carcinoma patients

SAMMARCO, INNOCENZO;ROSSI, PELLEGRINO;SETTE, CLAUDIO;GEREMIA, RAFFAELE
2004-11-01

Abstract

The proto-oncogene c-KIT encodes a tyrosine kinase receptor essential during embryonic development and postnatal life. Although deregulated expression of c-KIT has been reported, its role in colorectal carcinoma remains controversial: some authors have described a correlation between c-KIT expression and colorectal cancer (CRC), while others have failed to detect the receptor in the majority of neoplasia examined. To address this question, we designed a prospective study to analyze the expression of c-KIT in normal and neoplastic colonic mucosa of the same patient.
nov-2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/16 - ANATOMIA UMANA
English
Con Impact Factor ISI
Proto-Oncogene Proteins c-kit; Humans; Aged; Reverse Transcriptase Polymerase Chain Reaction; Carcinoma; Gene Expression Profiling; Blotting, Western; Prospective Studies; Aged, 80 and over; Middle Aged; Immunohistochemistry; Colorectal Neoplasms; Female; Male
Sammarco, I., Capurso, G., Coppola, L., Bonifazi, A., Cassetta, S., Delle Fave, G., et al. (2004). Expression of the proto-oncogene c-KIT in normal and tumor tissues from colorectal carcinoma patients. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 19(6), 545-553 [10.1007/s00384-004-0601-9].
Sammarco, I; Capurso, G; Coppola, L; Bonifazi, A; Cassetta, S; Delle Fave, G; Carrara, A; Grassi, G; Rossi, P; Sette, C; Geremia, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/40497
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