The proto-oncogene c-KIT encodes a tyrosine kinase receptor essential during embryonic development and postnatal life. Although deregulated expression of c-KIT has been reported, its role in colorectal carcinoma remains controversial: some authors have described a correlation between c-KIT expression and colorectal cancer (CRC), while others have failed to detect the receptor in the majority of neoplasia examined. To address this question, we designed a prospective study to analyze the expression of c-KIT in normal and neoplastic colonic mucosa of the same patient.
Sammarco, I., Capurso, G., Coppola, L., Bonifazi, A., Cassetta, S., Delle Fave, G., et al. (2004). Expression of the proto-oncogene c-KIT in normal and tumor tissues from colorectal carcinoma patients. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 19(6), 545-553 [10.1007/s00384-004-0601-9].
Expression of the proto-oncogene c-KIT in normal and tumor tissues from colorectal carcinoma patients
SAMMARCO, INNOCENZO;ROSSI, PELLEGRINO;SETTE, CLAUDIO;GEREMIA, RAFFAELE
2004-11-01
Abstract
The proto-oncogene c-KIT encodes a tyrosine kinase receptor essential during embryonic development and postnatal life. Although deregulated expression of c-KIT has been reported, its role in colorectal carcinoma remains controversial: some authors have described a correlation between c-KIT expression and colorectal cancer (CRC), while others have failed to detect the receptor in the majority of neoplasia examined. To address this question, we designed a prospective study to analyze the expression of c-KIT in normal and neoplastic colonic mucosa of the same patient.| File | Dimensione | Formato | |
|---|---|---|---|
|
Int J Col Dis 2004.pdf
accesso aperto
Descrizione: file pdf
Dimensione
264.41 kB
Formato
Adobe PDF
|
264.41 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
