Valproic acid is a well-known antiepileptic drug that was recently discovered to have a wide-spectrum antitumoral action in several tumors. In our work, we tested the proapoptotic activity of valproic acid in prostate cancer. Valproic acid-induced apoptosis was described by several in-vitro assays in three prostate cancer cell lines: two representing the prototype of advanced, clinically untreatable stages of prostate progression, PC3 and DU145, and one resembling a more differentiated androgen-sensitive tumor, LNCaP. We observed that valproic acid was a potent and early apoptotic inducer, mainly in less-differentiated prostate cancer cell lines. The molecular analysis of the apoptotic machinery involved in valproic acid action revealed a central role in Bcl-2 downmodulation. When prostate cancer cells were treated for a longer time with valproic acid, we detected an enhancement of Fas-dependent apoptosis associated with an overexpression in Fas and Fas ligand. Our data indicate that the use of valproic acid may be a suitable therapeutic agent in the control of prostate cancer progression and its action appears particularly relevant in the control of refractory stages of prostate cancer. Anti-Cancer Drugs 17:1141-1150 (c) 2006 Lippincott Williams & Wilkins.
Angelucci, A., Valentini, A., Millimaggi, D., Gravina, G.L., Miano, R., Dolo, V., et al. (2006). Valproic acid induces apoptosis in prostate carcinoma cell lines by activation of multiple death pathways. ANTI-CANCER DRUGS, 17(10), 1141-1150.
|Tipologia:||Articolo su rivista|
|Citazione:||Angelucci, A., Valentini, A., Millimaggi, D., Gravina, G.L., Miano, R., Dolo, V., et al. (2006). Valproic acid induces apoptosis in prostate carcinoma cell lines by activation of multiple death pathways. ANTI-CANCER DRUGS, 17(10), 1141-1150.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/24 - Urologia|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/01.cad.0000236302.89843.fc|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2006|
|Titolo:||Valproic acid induces apoptosis in prostate carcinoma cell lines by activation of multiple death pathways|
|Autori:||Angelucci, A; Valentini, A; Millimaggi, D; Gravina, GL; Miano, R; Dolo, V; Vicentini, C; Bologna, M; Federici, G; Bernardini, S|
|Appare nelle tipologie:||01 - Articolo su rivista|