Objective: To describe the treatment and long term outcome after immunosuppressive treatment of children with myocarditis. Methods and results: 114 patients with newly diagnosed dilated cardiomyopathy were divided into three groups, according to the histological pattern: group A, acute myocarditis; group B, borderline myocarditis; and group C, non-inflammatory cardiomyopathy. Groups A and B were treated with cyclosporine and prednisone in addition to conventional treatment. Survivors of the whole cohort were analysed for 13 year transplant-free survival and assessed for left ventricular function. Event-free survival at 13 years was 97 (3)% for group A, 70 (8)% for group B, and 32 (7)% for group C (p < 0.0001). It was 96 (4)% at one year and 83 (5)% at 13 years for the cumulated myocarditis group (A and B). Cardiac function recovered completely in 79% of survivors in group A, 64% in group B, and 36% in group C. The rate of complete recovery in the cumulated group (A and B) was 70%. Conclusions: The high long term survival rate of this cohort of children with myocarditis is probably due to the effect of short term immunosuppression. This result differs from previously published series of conventionally treated children, whose survival probability at one year was about 60%.

Giulia Gagliardi, M., Bevilacqua, M., Bassano, C., Leonardi, B., Boldrini, R., Diomedi Camassei, F., et al. (2004). Long term follow up of children with myocarditis treated by immunosuppression and of children with dilated cardiomyopathy. HEART, 90(10), 1167-1171 [10.1136/hrt.2003.026641].

Long term follow up of children with myocarditis treated by immunosuppression and of children with dilated cardiomyopathy

BASSANO, CARLO;
2004-01-01

Abstract

Objective: To describe the treatment and long term outcome after immunosuppressive treatment of children with myocarditis. Methods and results: 114 patients with newly diagnosed dilated cardiomyopathy were divided into three groups, according to the histological pattern: group A, acute myocarditis; group B, borderline myocarditis; and group C, non-inflammatory cardiomyopathy. Groups A and B were treated with cyclosporine and prednisone in addition to conventional treatment. Survivors of the whole cohort were analysed for 13 year transplant-free survival and assessed for left ventricular function. Event-free survival at 13 years was 97 (3)% for group A, 70 (8)% for group B, and 32 (7)% for group C (p < 0.0001). It was 96 (4)% at one year and 83 (5)% at 13 years for the cumulated myocarditis group (A and B). Cardiac function recovered completely in 79% of survivors in group A, 64% in group B, and 36% in group C. The rate of complete recovery in the cumulated group (A and B) was 70%. Conclusions: The high long term survival rate of this cohort of children with myocarditis is probably due to the effect of short term immunosuppression. This result differs from previously published series of conventionally treated children, whose survival probability at one year was about 60%.
2004
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore ICAR/01 - IDRAULICA
English
Con Impact Factor ISI
cyclosporin; immunosuppressive agent; prednisone; article; child; cohort analysis; congestive cardiomyopathy; congestive heart failure; controlled study; convalescence; dose response; drug dose reduction; female; follow up; heart left ventricle function; heart muscle biopsy; hirsutism; histopathology; human; human tissue; immunosuppressive treatment; major clinical study; male; myocarditis; pericardial effusion; priority journal; recurrent disease; survival rate; treatment outcome; Analysis of Variance; Biopsy; Cardiomyopathy, Dilated; Child, Preschool; Cyclosporine; Endocardium; Female; Follow-Up Studies; Heart Failure, Congestive; Humans; Immunosuppressive Agents; Infant; Male; Myocarditis; Prednisone; Ventricular Dysfunction, Left
Giulia Gagliardi, M., Bevilacqua, M., Bassano, C., Leonardi, B., Boldrini, R., Diomedi Camassei, F., et al. (2004). Long term follow up of children with myocarditis treated by immunosuppression and of children with dilated cardiomyopathy. HEART, 90(10), 1167-1171 [10.1136/hrt.2003.026641].
Giulia Gagliardi, M; Bevilacqua, M; Bassano, C; Leonardi, B; Boldrini, R; Diomedi Camassei, F; Fierabracci, A; Ugazio, A; Bottazzo, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/40469
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