Equine gastric ulcer syndrome (EGUS) is the most common disease of the stomach in horses and treat-ment is based on the oral administration of omeprazole for at least 28 days. aim of this study was to compare the efficacy of two formulations of oral omeprazole-powder paste and gastro-enteric resistant granules-in the treatment of naturally occurring gastric ulcers in racehorses. thirty-two adult racehorses, aged between 2 and 10 years old, with clinical signs of EGUS were included in this blinded, randomized clinical trial. two gastroscopies were performed to evaluate gastric lesions in the squamous or glandular mucosa before and after 28 days of treatment. after the first gastroscopy, 2/32 horses were excluded be-cause affected by equine squamous gastric disease (ESGD) 1/4. the remaining horses were divided into 4 groups, and were treated with 2 formulations of omeprazole (gastroenteric resistant granules, group 1, or powder paste, group 3) or with 2 placebo formulations (granules, group 2, or paste, group 4). treat-ments were performed in the placebo horses affected by ESGD or equine glandular gastric disease after the T28 gastroscopy control. no differences were found between groups at T0. Differences were found between T0 vs. T28 for granular ( P = .002) and powder paste ( P = .01) formulations. no differences were detected between the two groups receiving omeprazole formulations at T28 (0.34) and between T0 vs. T28 for either of the groups receiving placebo treatments. for all the variables, the size of the effect was greater than 0.5, proving that the treatments had a considerable effect. gastro-enteric resistant granules and powder paste omeprazole showed similar efficacy in the treatment of ESGD. the glandular mucosa responded poorly to treatment with omeprazole

Busechian, S., Conti, M., Sgorbini, M., Conte, G., Marchesi, M., Pieramati, C., et al. (2023). A comparison of the efficacy of two omeprazole formulations in the treatment of equine gastric ulcer syndrome in racehorses: a blinded, randomized clinical trial. JOURNAL OF EQUINE VETERINARY SCIENCE, 126 [10.1016/j.jevs.2023.104296].

A comparison of the efficacy of two omeprazole formulations in the treatment of equine gastric ulcer syndrome in racehorses: a blinded, randomized clinical trial

Busechian, S;
2023-01-01

Abstract

Equine gastric ulcer syndrome (EGUS) is the most common disease of the stomach in horses and treat-ment is based on the oral administration of omeprazole for at least 28 days. aim of this study was to compare the efficacy of two formulations of oral omeprazole-powder paste and gastro-enteric resistant granules-in the treatment of naturally occurring gastric ulcers in racehorses. thirty-two adult racehorses, aged between 2 and 10 years old, with clinical signs of EGUS were included in this blinded, randomized clinical trial. two gastroscopies were performed to evaluate gastric lesions in the squamous or glandular mucosa before and after 28 days of treatment. after the first gastroscopy, 2/32 horses were excluded be-cause affected by equine squamous gastric disease (ESGD) 1/4. the remaining horses were divided into 4 groups, and were treated with 2 formulations of omeprazole (gastroenteric resistant granules, group 1, or powder paste, group 3) or with 2 placebo formulations (granules, group 2, or paste, group 4). treat-ments were performed in the placebo horses affected by ESGD or equine glandular gastric disease after the T28 gastroscopy control. no differences were found between groups at T0. Differences were found between T0 vs. T28 for granular ( P = .002) and powder paste ( P = .01) formulations. no differences were detected between the two groups receiving omeprazole formulations at T28 (0.34) and between T0 vs. T28 for either of the groups receiving placebo treatments. for all the variables, the size of the effect was greater than 0.5, proving that the treatments had a considerable effect. gastro-enteric resistant granules and powder paste omeprazole showed similar efficacy in the treatment of ESGD. the glandular mucosa responded poorly to treatment with omeprazole
2023
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MVET-04/B - Clinica medica veterinaria
English
Equine
Gastro-resistant granules formulation
Powder paste formulation
Efficacy
ESGD
EGGD
Busechian, S., Conti, M., Sgorbini, M., Conte, G., Marchesi, M., Pieramati, C., et al. (2023). A comparison of the efficacy of two omeprazole formulations in the treatment of equine gastric ulcer syndrome in racehorses: a blinded, randomized clinical trial. JOURNAL OF EQUINE VETERINARY SCIENCE, 126 [10.1016/j.jevs.2023.104296].
Busechian, S; Conti, M; Sgorbini, M; Conte, G; Marchesi, M; Pieramati, C; Zappulla, F; Vitale, V; Rueca, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/403803
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