The ethiopathogenesis of rotator cuff disease remains poorly understood. Many studies advocate the importance of extra cellular matrix for the homeostasis of connective tissue. Transglutaminase enzymes family has been studied in the context of connective tissue formation and stabilisation. Here, we investigated transglutaminases expression pattern in biopsies of normal and injured supraspinatus tendons of human shoulders and in the Achilles tendons of transglutaminase 2 knock-out and wild-type mice. Our results show that different transglutaminase family members are differentially expressed in human and mouse tendons, and that transglutaminase 2 is down-regulated at mRNA and protein levels upon human supraspinatus tendon ruptures.

Oliva, F., Zocchi, L., Codispoti, A., Candi, E., Celi, M., Melino, G., et al. (2009). Transglutaminases expression in human supraspinatus tendon ruptures and in mouse tendons. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 379(4), 887-891 [10.1016/j.bbrc.2008.12.188].

Transglutaminases expression in human supraspinatus tendon ruptures and in mouse tendons

CANDI, ELEONORA;MELINO, GENNARO;TARANTINO, UMBERTO
2009-02-20

Abstract

The ethiopathogenesis of rotator cuff disease remains poorly understood. Many studies advocate the importance of extra cellular matrix for the homeostasis of connective tissue. Transglutaminase enzymes family has been studied in the context of connective tissue formation and stabilisation. Here, we investigated transglutaminases expression pattern in biopsies of normal and injured supraspinatus tendons of human shoulders and in the Achilles tendons of transglutaminase 2 knock-out and wild-type mice. Our results show that different transglutaminase family members are differentially expressed in human and mouse tendons, and that transglutaminase 2 is down-regulated at mRNA and protein levels upon human supraspinatus tendon ruptures.
20-feb-2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/33 - MALATTIE APPARATO LOCOMOTORE
English
Animals; Tendon Injuries; Humans; Transglutaminases; Aged; Rupture; GTP-Binding Proteins; Mice; RNA, Messenger; Mice, Mutant Strains; Rotator Cuff; Down-Regulation; Middle Aged; Female; Male
Oliva, F., Zocchi, L., Codispoti, A., Candi, E., Celi, M., Melino, G., et al. (2009). Transglutaminases expression in human supraspinatus tendon ruptures and in mouse tendons. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 379(4), 887-891 [10.1016/j.bbrc.2008.12.188].
Oliva, F; Zocchi, L; Codispoti, A; Candi, E; Celi, M; Melino, G; Maffulli, N; Tarantino, U
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/40257
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