Methods: This study assessed data from two cohorts of patients with alpha-synucleinopathies (University of Brescia and University of Rome Tor-Vergata cohorts). Consecutive participants with video-polysomnography-confirmed iRBD, Parkinson's disease (PD), dementia with Lewy bodies (DLB) and controls underwent neurological, clinical and 123I-FP-CIT SPECT imaging assessments. Individuals with iRBD were longitudinally monitored to collect clinical phenoconversion to PD or DLB. The main outcome was to identify whole brain 123 I-FP-CIT SPECT measures reflecting monoaminergic deficits in each clinical group as compared to controls. Results: The cohort (n = 184) included 45 patients with iRBD, 47 PD, 42 DLB and 50 age-matched controls. Individuals with iRBD were categorized as RBD-DAT− (n = 32) and RBD-DAT+ (n = 13), according to nigrostriatal assessment used in clinical practice. Compared to controls, RBD-DAT− showed an early involvement of the left insula, which increased in RBD-DAT+, and was present in patients with Parkinson's disease and dementia with Lewy bodies. Longitudinal cox regression analyses revealed a higher risk of phenoconversion in individuals with iRBD and insular monoaminergic deficits [HR = 3.387; CI 95%: 1.18–10.27]. Interpretation: In this study, altered insular monoaminergic binding in iRBD was associated with phenoconversion to DLB or PD. These findings may provide a helpful stratification approach for future pharmacological or non-pharmacological interventions.

Pilotto, A., Galli, A., Zatti, C., Placidi, F., Izzi, F., Premi, E., et al. (2024). Insular monoaminergic deficits in prodromal α-synucleinopathies. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 11(11), 2836-2845 [10.1002/acn3.52151].

Insular monoaminergic deficits in prodromal α-synucleinopathies

Placidi, Fabio;Izzi, Francesca;Mercuri, Nicola B;Fernandes, Mariana;Calvello, Carmen;Liguori, Claudio
2024-11-01

Abstract

Methods: This study assessed data from two cohorts of patients with alpha-synucleinopathies (University of Brescia and University of Rome Tor-Vergata cohorts). Consecutive participants with video-polysomnography-confirmed iRBD, Parkinson's disease (PD), dementia with Lewy bodies (DLB) and controls underwent neurological, clinical and 123I-FP-CIT SPECT imaging assessments. Individuals with iRBD were longitudinally monitored to collect clinical phenoconversion to PD or DLB. The main outcome was to identify whole brain 123 I-FP-CIT SPECT measures reflecting monoaminergic deficits in each clinical group as compared to controls. Results: The cohort (n = 184) included 45 patients with iRBD, 47 PD, 42 DLB and 50 age-matched controls. Individuals with iRBD were categorized as RBD-DAT− (n = 32) and RBD-DAT+ (n = 13), according to nigrostriatal assessment used in clinical practice. Compared to controls, RBD-DAT− showed an early involvement of the left insula, which increased in RBD-DAT+, and was present in patients with Parkinson's disease and dementia with Lewy bodies. Longitudinal cox regression analyses revealed a higher risk of phenoconversion in individuals with iRBD and insular monoaminergic deficits [HR = 3.387; CI 95%: 1.18–10.27]. Interpretation: In this study, altered insular monoaminergic binding in iRBD was associated with phenoconversion to DLB or PD. These findings may provide a helpful stratification approach for future pharmacological or non-pharmacological interventions.
nov-2024
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MEDS-12/A - Neurologia
English
Pilotto, A., Galli, A., Zatti, C., Placidi, F., Izzi, F., Premi, E., et al. (2024). Insular monoaminergic deficits in prodromal α-synucleinopathies. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 11(11), 2836-2845 [10.1002/acn3.52151].
Pilotto, A; Galli, A; Zatti, C; Placidi, F; Izzi, F; Premi, E; Caminiti, Sp; Presotto, L; Rizzardi, A; Catania, M; Lupini, A; Purin, L; Pasolini, Mp; ...espandi
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
ACN3-11-2836.pdf

accesso aperto

Licenza: Creative commons
Dimensione 702.34 kB
Formato Adobe PDF
702.34 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/402503
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact