After interruption of highly active antiretroviral therapy, 15 out of 53 patients with the X4 HIV strain had a significantly larger decrease in CD4(+) T cell count (P = 0.001) and shorter length of treatment interruption (P = 0.02) than patients with the R5 strain. At treatment resumption, HIV inferred tropism switched from the X4 strain to the R5 variant in 9 patients (60%). These patients had a prolonged length of treatment interruption compared to that of those who still carried the X4 strain.
Sarmati, L., Parisi, S., Andreoni, C., Nicastri, E., Buonomini, A., Boldrin, C., et al. (2010). Switching of inferred tropism caused by HIV during interruption of antiretroviral therapy. JOURNAL OF CLINICAL MICROBIOLOGY, 48(7), 2586-2588 [10.1128/JCM.02125-09].
Switching of inferred tropism caused by HIV during interruption of antiretroviral therapy
SARMATI, LOREDANA;MONTANO, MARCO;ANDREONI, MASSIMO
2010-07-01
Abstract
After interruption of highly active antiretroviral therapy, 15 out of 53 patients with the X4 HIV strain had a significantly larger decrease in CD4(+) T cell count (P = 0.001) and shorter length of treatment interruption (P = 0.02) than patients with the R5 strain. At treatment resumption, HIV inferred tropism switched from the X4 strain to the R5 variant in 9 patients (60%). These patients had a prolonged length of treatment interruption compared to that of those who still carried the X4 strain.| File | Dimensione | Formato | |
|---|---|---|---|
|
2125-09.pdf
accesso aperto
Dimensione
132.85 kB
Formato
Adobe PDF
|
132.85 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
