Background/Aim: Surgical stress has been correlated with higher rate of postoperative complications. Breast implants' surfaces (textured or smooth) represent an immunological stimulus. Our prospective study (BIAL2.20) evaluated post-operative leukocytes response at baseline and postoperative day (POD) 1 and 2 after implant-based breast reconstruction. Patients and Methods: Between January and July 2020, 41 patients underwent reconstruction with textured (n=23) or smooth (n=18) implants. A full blood count and lymphocyte subsets were collected before surgery, on POD1 and POD2. Data were evaluated as difference and relative difference from baseline by two-way analysis of variance test (2-way-ANOVA). Mann-Whitney U-test was performed at each POD, whenever between-group 2-way-ANOVA reached statistical significance. Results: Within-group-analysis showed statistically significant total leukocytosis in both groups. Within-group-analysis of lymphocytes subsets demonstrated statistically significant lymphopenia in the textured group for T-lymphocytes, and T-helper cells. Between-group-analysis showed statistically significant lymphopenia in T-helper subsets in the textured group at POD1 and POD2, when compared with the smooth group. Conclusion: Textured implants demonstrated a statistically significant impairment of T-helper trend during POD1 and POD2 when compared to smooth implants by between-group 2-way-ANOVA.

Vanni, G., Materazzo, M., Pellicciaro, M., Amir, S., Tacconi, F., Ambrogi, V., et al. (2021). Breast textured implants determine early T-helper impairment: BIAL2.20 study. ANTICANCER RESEARCH, 41(4), 2123-2132 [10.21873/anticanres.14984].

Breast textured implants determine early T-helper impairment: BIAL2.20 study

VANNI, GIANLUCA;MATERAZZO, MARCO;PELLICCIARO, MARCO;TACCONI, FEDERICO;AMBROGI, VINCENZO;BUONOMO, ORESTE CLAUDIO
2021-04-01

Abstract

Background/Aim: Surgical stress has been correlated with higher rate of postoperative complications. Breast implants' surfaces (textured or smooth) represent an immunological stimulus. Our prospective study (BIAL2.20) evaluated post-operative leukocytes response at baseline and postoperative day (POD) 1 and 2 after implant-based breast reconstruction. Patients and Methods: Between January and July 2020, 41 patients underwent reconstruction with textured (n=23) or smooth (n=18) implants. A full blood count and lymphocyte subsets were collected before surgery, on POD1 and POD2. Data were evaluated as difference and relative difference from baseline by two-way analysis of variance test (2-way-ANOVA). Mann-Whitney U-test was performed at each POD, whenever between-group 2-way-ANOVA reached statistical significance. Results: Within-group-analysis showed statistically significant total leukocytosis in both groups. Within-group-analysis of lymphocytes subsets demonstrated statistically significant lymphopenia in the textured group for T-lymphocytes, and T-helper cells. Between-group-analysis showed statistically significant lymphopenia in T-helper subsets in the textured group at POD1 and POD2, when compared with the smooth group. Conclusion: Textured implants demonstrated a statistically significant impairment of T-helper trend during POD1 and POD2 when compared to smooth implants by between-group 2-way-ANOVA.
apr-2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MEDS-06/A - Chirurgia generale
Settore MEDS-14/A - Chirurgia plastica
English
Breast cancer; Macrotextured implant; breast implant; breast reconstruction; immune function; immunological; leukocytes; lymphocytes; surgery; white blood cell
Vanni, G., Materazzo, M., Pellicciaro, M., Amir, S., Tacconi, F., Ambrogi, V., et al. (2021). Breast textured implants determine early T-helper impairment: BIAL2.20 study. ANTICANCER RESEARCH, 41(4), 2123-2132 [10.21873/anticanres.14984].
Vanni, G; Materazzo, M; Pellicciaro, M; Amir, S; Tacconi, F; Ambrogi, V; Buonomo, Oc
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/396729
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