background/aim: In 2016, in the united states, more than 50% of breast cancer (BC) cases were diagnosed in patients older than 60 years of age. our study aimed to estimate the risk of locoregional recurrence (LR) in patients who underwent breast-conservative treatment (BCT), according to age. patients and methods: this retrospective monocentric study analyzed 613 cases of patients who underwent BCT between 2003 and 2014. tpatients were divided into groups according to age: Under70 (under 70 years old) and over70 (above 70 years old). margins width, histology results, prognostic and predictive factors were compared. subgroup analysis was performed for patients who experienced LR. results: LR Incidence among tunder70 and over70 was 5.4% and 1.7%, respectively (p<0.01). group over70 is characterized by larger tumors and a lower Ki67 index (p<0.01). conclusion: operation time reduction, better aesthetic results and reduced LR risk support BCT. the over70 group exhibited better outcomes in terms of LR despite larger tumor dimensions.

Vanni, G., Materazzo, M., Pellicciaro, M., Morando, L., Portarena, I., Anemona, L., et al. (2020). Does Age Matter? Estimating Risks of Locoregional Recurrence After Breast-conservative Surgery. IN VIVO, 34(3) [10.21873/invivo.11884].

Does Age Matter? Estimating Risks of Locoregional Recurrence After Breast-conservative Surgery

Vanni, Gianluca;Materazzo, Marco;Pellicciaro, Marco;Anemona, Lucia;D'Angelillo, Maria Rolando;Chiaravalloti, Agostino;Meucci, Rosaria;Perretta, Tommaso;Orsaria, Paolo;Caspi, Jonathan;Pistolese, Chiara Adriana;Buonomo, Oreste Claudio
2020-01-01

Abstract

background/aim: In 2016, in the united states, more than 50% of breast cancer (BC) cases were diagnosed in patients older than 60 years of age. our study aimed to estimate the risk of locoregional recurrence (LR) in patients who underwent breast-conservative treatment (BCT), according to age. patients and methods: this retrospective monocentric study analyzed 613 cases of patients who underwent BCT between 2003 and 2014. tpatients were divided into groups according to age: Under70 (under 70 years old) and over70 (above 70 years old). margins width, histology results, prognostic and predictive factors were compared. subgroup analysis was performed for patients who experienced LR. results: LR Incidence among tunder70 and over70 was 5.4% and 1.7%, respectively (p<0.01). group over70 is characterized by larger tumors and a lower Ki67 index (p<0.01). conclusion: operation time reduction, better aesthetic results and reduced LR risk support BCT. the over70 group exhibited better outcomes in terms of LR despite larger tumor dimensions.
2020
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MEDS-06/A - Chirurgia generale
Settore MEDS-09/A - Oncologia medica
English
Breast cancer
breast cancer
breast-conservative treatment
elderly
tailored treatment
Vanni, G., Materazzo, M., Pellicciaro, M., Morando, L., Portarena, I., Anemona, L., et al. (2020). Does Age Matter? Estimating Risks of Locoregional Recurrence After Breast-conservative Surgery. IN VIVO, 34(3) [10.21873/invivo.11884].
Vanni, G; Materazzo, M; Pellicciaro, M; Morando, L; Portarena, I; Anemona, L; D'Angelillo, Mr; Barbarino, R; Chiaravalloti, A; Meucci, R; Perretta, T;...espandi
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
in_vivo-34-1125[1].pdf

solo utenti autorizzati

Tipologia: Versione Editoriale (PDF)
Licenza: Copyright dell'editore
Dimensione 177.5 kB
Formato Adobe PDF
177.5 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/396726
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 25
  • ???jsp.display-item.citation.isi??? 25
social impact