Shared strategies and correct information are essential to guide physicians in the management of such an uncommon disease as Breast Implant–Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). A systematic review of the literature was performed to collect the most relevant evidence on BIA-ALCL reported cases. A panel of multidisciplinary experts discussed the scientific evidence on BIA-ALCL, and updated consensus recommendations were developed through the Delphi process. The lastest reported Italian incidence of BIA-ALCL is 3.5 per 100.000 implanted patients (95% CI, 1.36 to 5.78), and the disease counts over 1216 cases worldwide as of June 2022. The most common presentation symptom is a late onset seroma followed by a palpable breast mass. In the event of a suspicious case, ultrasound-guided fine-needle aspiration should be the first step in evaluation, followed by cytologic and immunohistochemical examination. In patients with confirmed diagnosis of BIA-ALCL confined to the capsule, the en-bloc capsulectomy should be performed, followed by immediate autologous reconstruction, while delayed reconstruction applies for disseminate disease or radically unresectable tumor. Nevertheless, a multidisciplinary team approach is essential for the correct management of this pathology.

Longo, B., Di Napoli, A., Curigliano, G., Veronesi, P., Pileri, S., Martelli, M., et al. (2022). Clinical recommendations for diagnosis and treatment according to current updated knowledge on BIA-ALCL. THE BREAST, 66, 332-341 [10.1016/j.breast.2022.11.009].

Clinical recommendations for diagnosis and treatment according to current updated knowledge on BIA-ALCL

Longo, Benedetto;D'orsi, Gennaro;Giacalone, Martina;Storti, Gabriele;Cervelli, Valerio
2022-12-01

Abstract

Shared strategies and correct information are essential to guide physicians in the management of such an uncommon disease as Breast Implant–Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). A systematic review of the literature was performed to collect the most relevant evidence on BIA-ALCL reported cases. A panel of multidisciplinary experts discussed the scientific evidence on BIA-ALCL, and updated consensus recommendations were developed through the Delphi process. The lastest reported Italian incidence of BIA-ALCL is 3.5 per 100.000 implanted patients (95% CI, 1.36 to 5.78), and the disease counts over 1216 cases worldwide as of June 2022. The most common presentation symptom is a late onset seroma followed by a palpable breast mass. In the event of a suspicious case, ultrasound-guided fine-needle aspiration should be the first step in evaluation, followed by cytologic and immunohistochemical examination. In patients with confirmed diagnosis of BIA-ALCL confined to the capsule, the en-bloc capsulectomy should be performed, followed by immediate autologous reconstruction, while delayed reconstruction applies for disseminate disease or radically unresectable tumor. Nevertheless, a multidisciplinary team approach is essential for the correct management of this pathology.
dic-2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/19
Settore MEDS-14/A - Chirurgia plastica
English
breast reconstruction; breast implants; breast cancer; BIA-ALCL; anaplastic large cell lymphoma; ALCL
Longo, B., Di Napoli, A., Curigliano, G., Veronesi, P., Pileri, S., Martelli, M., et al. (2022). Clinical recommendations for diagnosis and treatment according to current updated knowledge on BIA-ALCL. THE BREAST, 66, 332-341 [10.1016/j.breast.2022.11.009].
Longo, B; Di Napoli, A; Curigliano, G; Veronesi, P; Pileri, S; Martelli, M; De Vita, R; Felici, N; Cirillo, P; Bernardi, C; D'Orsi, G; Giacalone, M; S...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/396287
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