Photobiostimulation Therapy (PBST) and Pulsed Electromagnetic Field Therapy (PEMF) in Hair Loss Treatment: Multicentric, Retrospective, Case–Control Study

BackgroundThe combined use of micro-needling (MND), growth factors (GFs), and low-level light/laser therapy (LLLT), here identified as photobiostimulation therapy (PBST) and pulsed electromagnetic field therapy (PEMF), is a hair loss (HL) treatment that needs to be standardized as it seems to have promising effects on hair regrowth (HR-G).ObjectivesThe study compared the clinical and instrumental results obtained in patients affected by androgenic alopecia (AGA) and HL related to COVID-19 treated using PEMF combined with PBST with those obtained by only PBST.MethodsA multicentric, retrospective, observational, case-control study was conducted. Fifty-three patients were initially enrolled (30 males classified as stages I-III vertex by the Norwood-Hamilton scale, while 23 females classified in stages I-II by the Ludwig scale). Forty patients (20 females and 20 males) were analyzed after exclusion and inclusion criteria assessment. Twenty patients were treated with the combined use of PEMF and PBST (study group - SG) while 20 patients were treated with PBST (control group -CG). The HR-G was evaluated through photography, physician's, and patient's global assessment scales, in addition to standardized phototrichograms, during a short follow-up at T0-baseline, T1-16 weeks.ResultsThe promising results in SG patients, represented by a hair count (HC) increase of 14 hairs/0.65 cm2 at T1 after 16 weeks in the targeted area, compared with the baseline results (41 +/- 2 hairs/0.65 cm2 at T1 versus 27 +/- 2 hairs/0.65 cm2 at baseline), were observed using computerized trichograms. There was a statistically significant difference in HR-G (p = 0.0325) compared with an HC increase of 11 +/- 2 hairs/0.65 cm2 in the CG.ConclusionsThe comparison between SG and CG indicated that PEMF combined with PBST was a more efficient strategy in HR-G in terms of HC improvement than PBST alone.Level of Evidence IIIThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.