The immunohistochemical determination of the Ki67 expression is regarded as a reliable method to monitor non-small cell lung cancer (NSCLC) proliferation. However, cancer tissues are not uniform and the use of a small tumor sample in biopsy may not be accurate. Although positron emission tomography (PET) represents an alternative to biopsy, by providing the 3-D functional and morphological distribution of cancer cells across the entire tumor volume, standardized uptake values (SUVs) exhibit poor accuracy. The purpose of this study is to identify quantitative features in 2-[F-18]FDG PET images uniquely correlated with proliferating lung cancer cells that may perform better than SUVs in the evaluation of lung cancer proliferation. By using a xenograft NSCLC model implanted in 19 mice, we found that 89 textural parameters extracted from 3-D 2-[F-18]FDG uptake can be described by 6 independent principal components accounting for 95% of the total variance. One of these components features a significant and univocal correlation with 3-D-stacked Ki67 staining immunohistochemical images (vertical bar r vertical bar > 0.6; P < 0.05/6, including compensation for multiple comparisons). Furthermore, the values of these components extracted from the PET images of in vivo and ex vivo explanted NSCLC cancers exhibit a strong correlation, verifying the stability of the segmentation method.

Hu, X., Liang, X., Antonecchia, E., Chiaravallotti, A., Chu, Q., Han, S., et al. (2022). 3-D Textural Analysis of 2-[¹F]FDG PET and Ki67 Expression in Nonsmall Cell Lung Cancer. IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES, 6(1), 113-120 [10.1109/TRPMS.2021.3051376].

3-D Textural Analysis of 2-[¹F]FDG PET and Ki67 Expression in Nonsmall Cell Lung Cancer

Schillaci O.;
2022-01-01

Abstract

The immunohistochemical determination of the Ki67 expression is regarded as a reliable method to monitor non-small cell lung cancer (NSCLC) proliferation. However, cancer tissues are not uniform and the use of a small tumor sample in biopsy may not be accurate. Although positron emission tomography (PET) represents an alternative to biopsy, by providing the 3-D functional and morphological distribution of cancer cells across the entire tumor volume, standardized uptake values (SUVs) exhibit poor accuracy. The purpose of this study is to identify quantitative features in 2-[F-18]FDG PET images uniquely correlated with proliferating lung cancer cells that may perform better than SUVs in the evaluation of lung cancer proliferation. By using a xenograft NSCLC model implanted in 19 mice, we found that 89 textural parameters extracted from 3-D 2-[F-18]FDG uptake can be described by 6 independent principal components accounting for 95% of the total variance. One of these components features a significant and univocal correlation with 3-D-stacked Ki67 staining immunohistochemical images (vertical bar r vertical bar > 0.6; P < 0.05/6, including compensation for multiple comparisons). Furthermore, the values of these components extracted from the PET images of in vivo and ex vivo explanted NSCLC cancers exhibit a strong correlation, verifying the stability of the segmentation method.
2022
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MEDS-22/A - Diagnostica per immagini e radioterapia
English
Nonsmall cell lung cancer (NSCLC)
preclinical positron emission tomography (PET) imaging
textural analysis
Hu, X., Liang, X., Antonecchia, E., Chiaravallotti, A., Chu, Q., Han, S., et al. (2022). 3-D Textural Analysis of 2-[¹F]FDG PET and Ki67 Expression in Nonsmall Cell Lung Cancer. IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES, 6(1), 113-120 [10.1109/TRPMS.2021.3051376].
Hu, X; Liang, X; Antonecchia, E; Chiaravallotti, A; Chu, Q; Han, S; Li, Z; Wan, L; D'Ascenzo, N; Schillaci, O; Xie, Q
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/394565
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