The Role of the "Anti-Inflammatory" Couple for the Management of Hyperuricemia With Deposition

introduction: gout is the most prevalent inflammatory crystal arthropathy worldwide and is a chronic disease requiring strict, lifelong adherence to drug therapy and healthy lifestyles. gout has a heavy burden on the patient's sexual health, owing to the associated inflammatory status, long-term complications, and chronic pain; however, the effects of gout also extend to the partner's sexual health.aims: we aimed to investigate how the presence of a partner could influence the complex interaction between risk factors for sexual dysfunctions in gout in order to define novel strategies to improve sexual health and disease management. methods: clinical and experimental data on the role of the couple in chronic diseases, as well as on the associa-tion between gout and sexual health, were searched through pubmed. main outcome measures: evidence from studies describing how the presence of a couple and leveraging sexual health can improve management and clinical outcomes for chronic diseases. results: treatment adherence can improve the sexual health of gout patients and their partners; likewise, by leveraging sexual health, it would be possible to promote better health-seeking behaviors, ultimately improving gout management. clinical implications: promoting awareness of the sexual health relevance of gout can potentially be a pivotal strategy to improve disease management and prevent the progression of sexual dysfunctions from subclinical to overt forms. strengths and limitations: identifying a bidirectional association between sexual health and disease manage-ment paves the way for improved disease control and can potentially prevent the development of sexual dysfunc-tions in couples affected by gout. however, the relevance of the couple has not been adequately addressed in gout management, and most evidence comes from other chronic diseases. conclusion: Improving gout management results in better sexualhealth, and vice-versa promoting better sexual health can improve disease control for gout. the presence of a partner improves the behavioral well-being of gout patients, with beneficial effects on both sexual health and gout management. sansone a, reisman y, meto s, et al. the role of the "anti-Inflammatory " couple for the management of hyperuricemia with deposi-tion. sex med 2022;XX:XXXXXX.