Peptides targeting shp2 and uses thereof

The present invention relates to a peptide having the sequence from N-terminus to C-terminus X-2X-1ZX1X2X3X4X5 whereinZ is tyrosine, phosphotyrosine or a non-natural analogue of phosphotyrosine, such as phosphonodifluoromethyl phenylalanine (F2Pmp)X-2 is a hydrophobic amino acid, such as Leu, Ile, Val, Phe, Tyr, Trp and MetX-1 is any amino acidX1 is a hydrophobic amino acid, such as Ile, Leu, Val, Phe, Tyr, Trp and MetX3 is a hydrophobic amino acid, such as Leu, Ile, Val, Phe, Tyr, Trp and MetX5 is a hydrophobic amino acid, such as Trp, Ile, Val, Phe, Tyr, and MetX2 and X4 are anionic amino acids, preferably each independently is Asp or Glu.The peptide inhibits protein-protein interactions of the Src homology 2 domain-containing phosphatase 2 (SHP2), for the treatment of cancer and RASopathies and as a biomedical research tool.