Cushing syndrome (CS) is certainly one of the most challenging endocrine disorders. The greatest problem involves the differentiation between Cushing disease and ectopic ACTH syndrome. We report a patient with ACTH-dependent CS who elsewhere underwent unsuccessful transsphenoidal surgery for a pituitary microadenoma. In our institution, high resolution CT didn't show any chest tumor but laboratory data were consistent with ectopic ACTH secretion.Only In-111 Octreoscan, integrated with SPECT-CT and virtual bronchoscopy, allowed the diagnosis of ectopic Cushing syndrome due to occult bronchial carcinoid. Successful surgery was then performed. © 2009 by Lippincott Williams & Wilkins.
Corsello, S., Fintini, D., Lovicu, R., Paragliola, R., Rufini, V., Simonetti, G., et al. (2009). Ectopic ACTH syndrome due to occult bronchial carcinoid. CLINICAL NUCLEAR MEDICINE, 34(7), 459-461 [10.1097/RLU.0b013e3181a7d22e].
Ectopic ACTH syndrome due to occult bronchial carcinoid
SIMONETTI, GIOVANNI MARIA EGISTO;
2009-01-01
Abstract
Cushing syndrome (CS) is certainly one of the most challenging endocrine disorders. The greatest problem involves the differentiation between Cushing disease and ectopic ACTH syndrome. We report a patient with ACTH-dependent CS who elsewhere underwent unsuccessful transsphenoidal surgery for a pituitary microadenoma. In our institution, high resolution CT didn't show any chest tumor but laboratory data were consistent with ectopic ACTH secretion.Only In-111 Octreoscan, integrated with SPECT-CT and virtual bronchoscopy, allowed the diagnosis of ectopic Cushing syndrome due to occult bronchial carcinoid. Successful surgery was then performed. © 2009 by Lippincott Williams & Wilkins.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.