OBJECTIVE: Platelet derived growth factor (PDGF) is involved in the development of leiomyomas. The low-molecular-weight phosphoprotein-tyrosine-phosphatase (LMWPTP), controlled by the highly polymorphic acid phosphatase locus 1 (ACP1), is able to dephosphorylate the PDGF receptor. Therefore, we searched for a possible association between ACP1 and leiomyomas. STUDY DESIGN: We studied 172 women hospitalized for symptomatic leiomyomas requiring surgical intervention and 164 healthy women without clinical evidence of leiomyomas from the same white population. The chi(2) test of independence, Pearson correlation, analysis of variance, and post hoc test for difference between means were performed. RESULTS: The distribution of ACP1 genotypes among patients does not differ significantly from that of healthy women. However, leiomyoma size was negatively correlated with ACP1 F isoform concentrations. Leiomyoma size was smaller among carriers of the *B/*B genotype, which has the highest concentration of the F isoform, than among carriers of *A/*A, *C/*B, and *C/*C genotypes, which have the lowest concentration of the F isoform. CONCLUSION: High ACP1 F isoform concentration, through dephosphorylation of the PDGF receptor, may negatively regulate cell proliferation and growth of leiomyomas.
Ammendola M.L., P.A. (2009). Is there an association between uterine leiomyomas and acid phosphatase locus 1 polymorphism?. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 200(1).
|Tipologia:||Articolo su rivista|
|Citazione:||Ammendola M.L., P.A. (2009). Is there an association between uterine leiomyomas and acid phosphatase locus 1 polymorphism?. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 200(1).|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/40 - Ginecologia e Ostetricia|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ajog.2008.07.033|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2009|
|Titolo:||Is there an association between uterine leiomyomas and acid phosphatase locus 1 polymorphism?|
|Autori:||Ammendola M.L., Pietropolli A., Lista F., Saccucci P., Piccione E., Bottini E., Gloria-Bottini F.|
|Appare nelle tipologie:||01 - Articolo su rivista|