Since Carbon Nanotubes (CNT) have been only recently introduced into the market, clinical and epidemiological evidence for establishing whether these can affect the cardiovascular system or can exacerbate certain pre-existing medical conditions is lacking. In vitro tests assessing the Quantitative Structure-Activity Relationship (QSAR) may help to identify the hazardous properties, whereas in vivo studies could improve our understanding of the biokinetics and effects on target organs. The results from experimental studies suggest that CNT may pose a health hazard to employees and underscore the need for preventive measures. Owing to the biopersistency of CNT, short-term inhalation studies seem inadequate to identify what disease endpoints should be considered in occupational medical surveillance. In spite of this uncertainty, mechanistic in vitro/in vivo studies, using well-characterised nanomaterials and pointing to the dose response assessment, can improve our ability to move from laboratory science towards a sound management of the possible health impact of this new class of chemicals. Copyright © 2009, Inderscience Publishers.

Bergamaschi, E., Iavicoli, I., Bussolati, O., Pietroiusti, A., Magrini, A., Bergamaschi, A. (2009). A toxicological approach to hazard assessment of carbon nanotubes: Implications for workers' health protection. INTERNATIONAL JOURNAL OF ENVIRONMENT AND HEALTH, 3(3), 249-263 [10.1504/IJENVH.2009.028590].

A toxicological approach to hazard assessment of carbon nanotubes: Implications for workers' health protection

PIETROIUSTI, ANTONIO;MAGRINI, ANDREA;
2009

Abstract

Since Carbon Nanotubes (CNT) have been only recently introduced into the market, clinical and epidemiological evidence for establishing whether these can affect the cardiovascular system or can exacerbate certain pre-existing medical conditions is lacking. In vitro tests assessing the Quantitative Structure-Activity Relationship (QSAR) may help to identify the hazardous properties, whereas in vivo studies could improve our understanding of the biokinetics and effects on target organs. The results from experimental studies suggest that CNT may pose a health hazard to employees and underscore the need for preventive measures. Owing to the biopersistency of CNT, short-term inhalation studies seem inadequate to identify what disease endpoints should be considered in occupational medical surveillance. In spite of this uncertainty, mechanistic in vitro/in vivo studies, using well-characterised nanomaterials and pointing to the dose response assessment, can improve our ability to move from laboratory science towards a sound management of the possible health impact of this new class of chemicals. Copyright © 2009, Inderscience Publishers.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/44 - Medicina del Lavoro
English
Con Impact Factor ISI
Carbon nanotubes; Environmental health; Hazard assessment
Bergamaschi, E., Iavicoli, I., Bussolati, O., Pietroiusti, A., Magrini, A., Bergamaschi, A. (2009). A toxicological approach to hazard assessment of carbon nanotubes: Implications for workers' health protection. INTERNATIONAL JOURNAL OF ENVIRONMENT AND HEALTH, 3(3), 249-263 [10.1504/IJENVH.2009.028590].
Bergamaschi, E; Iavicoli, I; Bussolati, O; Pietroiusti, A; Magrini, A; Bergamaschi, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/39190
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