A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system.

Gattinoni, S., Simone, C., Dallavalle, S., Fezza, F., Nannei, R., Battista, N., et al. (2010). A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(15), 4406-4411 [10.1016/j.bmcl.2010.06.050].

A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase

FEZZA, FILOMENA;
2010-01-01

Abstract

A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system.
2010
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/10 - BIOCHIMICA
English
http://dx.doi.org/10.1016/j.bmcl.2010.06.050
Gattinoni, S., Simone, C., Dallavalle, S., Fezza, F., Nannei, R., Battista, N., et al. (2010). A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(15), 4406-4411 [10.1016/j.bmcl.2010.06.050].
Gattinoni, S; Simone, C; Dallavalle, S; Fezza, F; Nannei, R; Battista, N; Minetti, P; Quattrociocchi, G; Caprioli, A; Borsini, F; Cabri, W; Penco, S; Merlini, L; Maccarrone, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/39186
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