we report a case of an elderly patient with metastatic castration-resistant prostate cancer, initially treated with abiraterone acetate (1,000 mg/day) combined with LH-RH antagonist, prednisone (10 mg/day), and zoledronic acid to manage bone metastases. In consideration of his poor performance status, radiological and biochemical progression of the disease, we decided to switch abiraterone to enzalutamide (160 mg/day). due to adverse events, we reduced enzalutamide to a dose of 80 mg/day. currently, the disease is under control despite the use of a low dose of enzalutamide.

Rossi, L., Cimino, G., Gozzi, E., Sinjari, M., Brandi, M., Ceddia, S., et al. (2021). Stunning Response with Low-Dose Enzalutamide after Abiraterone Acetate Failure in a Patient Diagnosed with Metastatic Castration-Resistant Prostate Cancer: A Case Report. CASE REPORTS IN ONCOLOGY [10.1159/000514979].

Stunning Response with Low-Dose Enzalutamide after Abiraterone Acetate Failure in a Patient Diagnosed with Metastatic Castration-Resistant Prostate Cancer: A Case Report

Filippi L;
2021-01-01

Abstract

we report a case of an elderly patient with metastatic castration-resistant prostate cancer, initially treated with abiraterone acetate (1,000 mg/day) combined with LH-RH antagonist, prednisone (10 mg/day), and zoledronic acid to manage bone metastases. In consideration of his poor performance status, radiological and biochemical progression of the disease, we decided to switch abiraterone to enzalutamide (160 mg/day). due to adverse events, we reduced enzalutamide to a dose of 80 mg/day. currently, the disease is under control despite the use of a low dose of enzalutamide.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MEDS-22/A - Diagnostica per immagini e radioterapia
English
Abiraterone; Bone metastases; Enzalutamide; Metastatic castration-resistant prostate cancer; PSA.
Rossi, L., Cimino, G., Gozzi, E., Sinjari, M., Brandi, M., Ceddia, S., et al. (2021). Stunning Response with Low-Dose Enzalutamide after Abiraterone Acetate Failure in a Patient Diagnosed with Metastatic Castration-Resistant Prostate Cancer: A Case Report. CASE REPORTS IN ONCOLOGY [10.1159/000514979].
Rossi, L; Cimino, G; Gozzi, E; Sinjari, M; Brandi, M; Ceddia, S; Cosimati, A; Raimondi, L; Fontana, A; Filippi, L; Bagni, O; Spinelli, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/390668
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