3'-Deoxy-4'-azaribonucleosides (15a-d) were synthesized starting from the commercially available (4R)-trans-4-hydroxy-L-proline 7. From biological evaluations, 15b and 15d emerged as potent inhibitors of HCV replication on a replicon assay. These findings demonstrate that synthesized pyrrolidine nucleosides represent a new template for antiviral or other biological studies and could be considered for novel combination therapy against HCV infection using nucleoside inhibitors and non-nucleoside inhibitors of HCV NS5B.
Chiacchio, U., Borrello, L., Crispino, L., Rescifina, A., Merino, P., Macchi, B., et al. (2009). Stereoselective Synthesis and Biological Evaluations of Novel 3 '-Deoxy-4 '-azaribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication. JOURNAL OF MEDICINAL CHEMISTRY, 52(13), 4054-4057.
Tipologia: | Articolo su rivista |
Citazione: | Chiacchio, U., Borrello, L., Crispino, L., Rescifina, A., Merino, P., Macchi, B., et al. (2009). Stereoselective Synthesis and Biological Evaluations of Novel 3 '-Deoxy-4 '-azaribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication. JOURNAL OF MEDICINAL CHEMISTRY, 52(13), 4054-4057. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/14 Settore CHIM/06 - Chimica Organica Settore MED/07 - Microbiologia e Microbiologia Clinica |
Revisione (peer review): | Esperti anonimi |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1021/jm900197j |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2009 |
Titolo: | Stereoselective Synthesis and Biological Evaluations of Novel 3 '-Deoxy-4 '-azaribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication |
Autori: | |
Autori: | Chiacchio, U; Borrello, L; Crispino, L; Rescifina, A; Merino, P; Macchi, B; Balestrieri, E; Mastino, A; Piperno, A; Romeo, G |
Appare nelle tipologie: | 01 - Articolo su rivista |
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