a 54-year-old woman with metastatic colorectal carcinoma underwent liver radioembolization with (90)Y resin microspheres. microsphere biodistribution was assessed 2 h after the treatment through a 20-min long (90)Y PET scan. Isodose map and lesion dose-volume histogram (DVH) were then evaluated using a MATLAB-based code. response to therapy was assessed performing a (18)F-FDG PET 6 months after the treatment. at (90)Y PET the patient showed a well-defined horseshoe-shaped hepatic lesion with hot margins and a cold core. the lesion presented a heterogeneous DVH with a hot margin receiving an average radiation dose as high as 287 gy and a cold area receiving an average radiation dose of 70 gy approximately. six months after the treatment the patient reported a complete remission of tumour areas which received a high radiation dose, while progression of metastases was observed in the area that presented scarce microsphere localization at (90)Y PET. according to our experience, the use of (90)Y PET voxel dosimetry may provide a useful tool to assess possible correlations between microsphere biodistribution and clinical outcome of the treatment. in agreement with current literature findings, an average radiation dose greater than approximately 100 Gy may be required to sterilize liver metastases.

D'Arienzo, M., Filippi, L., Chiaramida, P., Chiacchiararelli, L., Cianni, R., Salvatori, R., et al. (2013). Absorbed dose to lesion and clinical outcome after liver radioembolization with 90Y microspheres: a case report of PET-based dosimetry. ANNALS OF NUCLEAR MEDICINE, 27, 676-680 [10.1007/s12149-013-0726-4].

Absorbed dose to lesion and clinical outcome after liver radioembolization with 90Y microspheres: a case report of PET-based dosimetry

Filippi L;
2013-01-01

Abstract

a 54-year-old woman with metastatic colorectal carcinoma underwent liver radioembolization with (90)Y resin microspheres. microsphere biodistribution was assessed 2 h after the treatment through a 20-min long (90)Y PET scan. Isodose map and lesion dose-volume histogram (DVH) were then evaluated using a MATLAB-based code. response to therapy was assessed performing a (18)F-FDG PET 6 months after the treatment. at (90)Y PET the patient showed a well-defined horseshoe-shaped hepatic lesion with hot margins and a cold core. the lesion presented a heterogeneous DVH with a hot margin receiving an average radiation dose as high as 287 gy and a cold area receiving an average radiation dose of 70 gy approximately. six months after the treatment the patient reported a complete remission of tumour areas which received a high radiation dose, while progression of metastases was observed in the area that presented scarce microsphere localization at (90)Y PET. according to our experience, the use of (90)Y PET voxel dosimetry may provide a useful tool to assess possible correlations between microsphere biodistribution and clinical outcome of the treatment. in agreement with current literature findings, an average radiation dose greater than approximately 100 Gy may be required to sterilize liver metastases.
2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MEDS-22/A - Diagnostica per immagini e radioterapia
English
D'Arienzo, M., Filippi, L., Chiaramida, P., Chiacchiararelli, L., Cianni, R., Salvatori, R., et al. (2013). Absorbed dose to lesion and clinical outcome after liver radioembolization with 90Y microspheres: a case report of PET-based dosimetry. ANNALS OF NUCLEAR MEDICINE, 27, 676-680 [10.1007/s12149-013-0726-4].
D'Arienzo, M; Filippi, L; Chiaramida, P; Chiacchiararelli, L; Cianni, R; Salvatori, R; Scopinaro, F; Bagni, O
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/390564
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