background: the effectiveness of 18F-fluorodeoxyglucose (18F-FDG) positron emission computed tomography (PET/CT) for monitoring response to immunotherapy (IT) with cemiplimab in patients affected by cutaneous squamocellular carcinoma (cSCC) was investigated. materials and methods: thirteen cSCC patients performed PET/CT at baseline (PET-1) and 3 months after IT (PET-2). according to immune PET response criteria in solid tumors (iPERCIST), patients showing progressive disease at PET-2 were classified as having "unconfirmed progressive metabolic disease" (uPMD) and were scheduled to perform a further PET/CT (PET-3) after 4 weeks. PET/CT's results were correlated with best clinical response (BCR) categorized, within 6 months from the start of IT, as clinical benefit (CB) or no clinical benefit (NCB) according to clinical follow-up. results: at PET-2, 9 subjects (69.2%) showed metabolic response, whereas four (30.8%) were classified as uPMD. after 4 weeks, three uPMD patients were subjected to PET-3, which confirmed progressive disease in all cases, whereas 1 patient with uPMD did not undergo PET-3 due to clinical deterioration. all subjects with metabolic response at PET-2 were classified as having CB and continued IT in 8 out of 9 cases, whereas all patients with uPMD were categorized as NCB and discontinued IT. conclusions: PET/CT, performed in cSCC patients after 3 months of cemiplimab, resulted capable to identify responders from nonresponders.

Filippi, L., Proietti, I., Petrozza, V., Bagni, O., Schillaci, O. (2022). Cutaneous Squamous Cell Carcinoma Subjected to Anti PD-1 Immunotherapy: Monitoring Response Through Serial PET/CT Scans with 18F-FDG. CANCER BIOTHERAPY & RADIOPHARMACEUTICALS [10.1089/cbr.2021.0368].

Cutaneous Squamous Cell Carcinoma Subjected to Anti PD-1 Immunotherapy: Monitoring Response Through Serial PET/CT Scans with 18F-FDG

Filippi L;
2022-01-01

Abstract

background: the effectiveness of 18F-fluorodeoxyglucose (18F-FDG) positron emission computed tomography (PET/CT) for monitoring response to immunotherapy (IT) with cemiplimab in patients affected by cutaneous squamocellular carcinoma (cSCC) was investigated. materials and methods: thirteen cSCC patients performed PET/CT at baseline (PET-1) and 3 months after IT (PET-2). according to immune PET response criteria in solid tumors (iPERCIST), patients showing progressive disease at PET-2 were classified as having "unconfirmed progressive metabolic disease" (uPMD) and were scheduled to perform a further PET/CT (PET-3) after 4 weeks. PET/CT's results were correlated with best clinical response (BCR) categorized, within 6 months from the start of IT, as clinical benefit (CB) or no clinical benefit (NCB) according to clinical follow-up. results: at PET-2, 9 subjects (69.2%) showed metabolic response, whereas four (30.8%) were classified as uPMD. after 4 weeks, three uPMD patients were subjected to PET-3, which confirmed progressive disease in all cases, whereas 1 patient with uPMD did not undergo PET-3 due to clinical deterioration. all subjects with metabolic response at PET-2 were classified as having CB and continued IT in 8 out of 9 cases, whereas all patients with uPMD were categorized as NCB and discontinued IT. conclusions: PET/CT, performed in cSCC patients after 3 months of cemiplimab, resulted capable to identify responders from nonresponders.
2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MEDS-22/A - Diagnostica per immagini e radioterapia
English
18F-FDG; PET/CT; cutaneous squamous cell carcinoma; immunotherapy; precision medicine.
Filippi, L., Proietti, I., Petrozza, V., Bagni, O., Schillaci, O. (2022). Cutaneous Squamous Cell Carcinoma Subjected to Anti PD-1 Immunotherapy: Monitoring Response Through Serial PET/CT Scans with 18F-FDG. CANCER BIOTHERAPY & RADIOPHARMACEUTICALS [10.1089/cbr.2021.0368].
Filippi, L; Proietti, I; Petrozza, V; Bagni, O; Schillaci, O
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/390561
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