high-risk acute myeloid leukemia has been associated with a poor outcome. hematopoietic stem cell transplantation (HSCT) represents the only curative option for eligible patients. relapse after HSCT is a dramatic event with poor chances of survival. with the aim of reducing the rate of post-HSCT relapse, maintenance treatment has been investigated in this setting. results from clinical trials suggest an advantage in the use of a maintenance strategy; however, standardized guidelines are not yet available due to the lack of prospective clinical trials. In this review, we have reported the most important strategies adopted as post-HSCT maintenance, highlighting their efficacy, but the current research also opens questions.
Canichella, M., Molica, M., Mazzone, C., de Fabritiis, P. (2024). Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia. CURRENT ONCOLOGY, 31(10), 6050-6060 [10.3390/curroncol31100451].
Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia
Mazzone, Carla;de Fabritiis, Paolo
2024-10-10
Abstract
high-risk acute myeloid leukemia has been associated with a poor outcome. hematopoietic stem cell transplantation (HSCT) represents the only curative option for eligible patients. relapse after HSCT is a dramatic event with poor chances of survival. with the aim of reducing the rate of post-HSCT relapse, maintenance treatment has been investigated in this setting. results from clinical trials suggest an advantage in the use of a maintenance strategy; however, standardized guidelines are not yet available due to the lack of prospective clinical trials. In this review, we have reported the most important strategies adopted as post-HSCT maintenance, highlighting their efficacy, but the current research also opens questions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
