Time In Tight Range in children and adolescents with type 1 diabetes: A cross-sectional observational single centre study evaluating efficacy of new advanced technologies

introduction early and tight glycaemic control is crucial to prevent long-term complications of type 1 diabetes (T1D). the aim of our study was to compare glucose metrics, including time In Tight Range (TITR), in a real-world setting. methodsWe performed a single-centre cross-sectional study in 534 children and adolescents with T1D. participants were divided into four groups (multiple daily injections + real-time continuous glucose monitoring (CGM), multiple daily injections + intermittently scanned CGM, sensor augmented pump (SAP), and advanced hybrid closed-Loop (AHCL). demographical and clinical data were collected and analysed. results the group with AHCL showed significantly higher time In range (TIR) (71.31% +/- 10.88) than SAP (57.82% +/- 14.98; p < 0.001), MDI + rtCGM (54.56% +/- 17.04; p < 0.001) and MDI + isCGM (52.17% +/- 19.36; p < 0.001) groups with a lower time above range (p < 0.001). the group with AHCL also showed lower time below range than MDI + isCGM and SAP groups (p < 0.01). the overall TITR was 37% +/- 14 with 19% of participants who reached a TITR >= 50% with a mean TIR of 81%. AHCL had significantly higher TITR (45.46% +/- 11.77) than SAP (36.25% +/- 13.53; p < 0.001), MDI + rtCGM (34.03% +/- 13.89; p < 0.001) and MDI + isCGM (33.37% +/- 15.84; p < 0.001) groups with a lower coefficient of variation (p < 0.001). conclusions our study indicates that AHCL ensures a better glycaemic control with an improvement in both TIR and TITR, along with a reduction in CV. Implementation of automated insulin delivery systems should be considered in the treatment of children and adolescents with T1D.