The quest for eternal youth has been prevalent in civilised societies in many cultures for many centuries. Preventing or deferring the disabilities and morbidities associated with aging through judicious pharmacotherapy has become a particularly relevant healthcare target with the rapid and relentless global demographic shift towards an increasingly elderly population in the 21th century. Aging men commonly loose muscle, become frail, have impaired sexual and cognitive functions, low mood, develop osteopenia and/or osteoporosis with increased risk for fractures and gain visceral fat which predisposes to diabetes, dyslipidaemia, and ischemic heart disease. These alterations in body function are reminiscent of states of androgen deficiency in younger patients. Indeed, aging is associated with a progressive age-related but variable decline in sex hormones. This condition has been named partial androgen deficiency in aging men (PADAM) and consists in a gradual decline in sex hormone levels over years resulting in physical and psychological changes as depression, impotence, decreased sex drive, loss of muscle tone or strength and lethargy. In this review we have tried to give a real identity to PADAM and quantify its entitiy, using the power of the epidemiology.

Frajese, G., De Martino, M., Calcagni, E., Pastore, R., Caprio, M., Bultrini, A., et al. (2005). The epidemiology of partialandrogen deficiency in aging men (PADAM). JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 28(3 Suppl), 3-7.

The epidemiology of partialandrogen deficiency in aging men (PADAM)

FRAJESE, GAETANO;PASTORE, RENATO;CAPRIO, MASSIMILIANO;MORETTI, COSTANZO;FABBRI, ANDREA
2005-01-01

Abstract

The quest for eternal youth has been prevalent in civilised societies in many cultures for many centuries. Preventing or deferring the disabilities and morbidities associated with aging through judicious pharmacotherapy has become a particularly relevant healthcare target with the rapid and relentless global demographic shift towards an increasingly elderly population in the 21th century. Aging men commonly loose muscle, become frail, have impaired sexual and cognitive functions, low mood, develop osteopenia and/or osteoporosis with increased risk for fractures and gain visceral fat which predisposes to diabetes, dyslipidaemia, and ischemic heart disease. These alterations in body function are reminiscent of states of androgen deficiency in younger patients. Indeed, aging is associated with a progressive age-related but variable decline in sex hormones. This condition has been named partial androgen deficiency in aging men (PADAM) and consists in a gradual decline in sex hormone levels over years resulting in physical and psychological changes as depression, impotence, decreased sex drive, loss of muscle tone or strength and lethargy. In this review we have tried to give a real identity to PADAM and quantify its entitiy, using the power of the epidemiology.
2005
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/13 - ENDOCRINOLOGIA
English
Con Impact Factor ISI
Obesity; Hypogonadism; Epidemiology; Aged, 80 and over; Risk Factors; Humans; Diabetes Mellitus, Type 2; Aging; Aged; Male; Androgens
PMID: 16042354
Frajese, G., De Martino, M., Calcagni, E., Pastore, R., Caprio, M., Bultrini, A., et al. (2005). The epidemiology of partialandrogen deficiency in aging men (PADAM). JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 28(3 Suppl), 3-7.
Frajese, G; De Martino, M; Calcagni, E; Pastore, R; Caprio, M; Bultrini, A; Moretti, C; Frajese, G; Fabbri, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/38950
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