iIn sub-saharan africa the great majority of infants acquire cytomegalovirus (CMV) infection within the first year of life. maternal long-term antiretroviral therapy (ART) has been suggested to reduce the rate of CMV acquisition in HIV-exposed infants. In the present study serum samples collected at 6 months of age from HIV-exposed and HIV-unexposed infants were analyzed for the presence of CMV DNA (with CMV positivity defined by levels of CMV DNA > 1000 UI/ml). twenty out of 58 (34.5%) infants had CMV DNA > 1000 UI/ml. there was no difference in the prevalence of CMV viremia between HIV-exposed and -unexposed infants [33.3% (15/45) vs 38.5% (5/13), respectively, P = 0.488]. In the HIV-exposed group, mothers of CMV-negative infants had received a longer antiretroviral treatment before delivery in comparison to mothers of CMV-positive infants (28 vs 3 months, P = 0.187). no differences in weights and lengths at birth, and at 1, 6 and 12 months were observed between CMV-positive and CMV-negative infants. In this study, the prevalence of CMV viremia at six months of age was high in infants born to HIV-positive mothers receiving long-term ART, similar to that of HIV-unexposed infants. considering the possible relevant impact of CMV on infant health, strategies for containment of the infection should be explored.

Giuliano, M., Pirillo, M.f., Orlando, S., Luhanga, R., Mphwere, R., Kavalo, T., et al. (2023). Cytomegalovirus viremia in HIV-exposed and HIV-unexposed infants in Malawi. ACTA TROPICA, 246 [10.1016/j.actatropica.2023.106987].

Cytomegalovirus viremia in HIV-exposed and HIV-unexposed infants in Malawi

Orlando, S.;Ciccacci, F.;
2023-01-01

Abstract

iIn sub-saharan africa the great majority of infants acquire cytomegalovirus (CMV) infection within the first year of life. maternal long-term antiretroviral therapy (ART) has been suggested to reduce the rate of CMV acquisition in HIV-exposed infants. In the present study serum samples collected at 6 months of age from HIV-exposed and HIV-unexposed infants were analyzed for the presence of CMV DNA (with CMV positivity defined by levels of CMV DNA > 1000 UI/ml). twenty out of 58 (34.5%) infants had CMV DNA > 1000 UI/ml. there was no difference in the prevalence of CMV viremia between HIV-exposed and -unexposed infants [33.3% (15/45) vs 38.5% (5/13), respectively, P = 0.488]. In the HIV-exposed group, mothers of CMV-negative infants had received a longer antiretroviral treatment before delivery in comparison to mothers of CMV-positive infants (28 vs 3 months, P = 0.187). no differences in weights and lengths at birth, and at 1, 6 and 12 months were observed between CMV-positive and CMV-negative infants. In this study, the prevalence of CMV viremia at six months of age was high in infants born to HIV-positive mothers receiving long-term ART, similar to that of HIV-unexposed infants. considering the possible relevant impact of CMV on infant health, strategies for containment of the infection should be explored.
2023
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MEDS-24/B - Igiene generale e applicata
English
CMV DNA
Cytomegalovirus
HIV-exposed infant
Malawi
Giuliano, M., Pirillo, M.f., Orlando, S., Luhanga, R., Mphwere, R., Kavalo, T., et al. (2023). Cytomegalovirus viremia in HIV-exposed and HIV-unexposed infants in Malawi. ACTA TROPICA, 246 [10.1016/j.actatropica.2023.106987].
Giuliano, M; Pirillo, Mf; Orlando, S; Luhanga, R; Mphwere, R; Kavalo, T; Andreotti, M; Amici, R; Ciccacci, F; Marazzi, Mc; Floridia, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/388781
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