Nanomaterials and cross-cutting technologies for fostering smart electrochemical biosensors in the detection of chemical warfare agents

The smart, rapid, and customizable detection of chemical warfare agents is a huge issue for taking the proper countermeasures in a timely fashion. The printing techniques have established the main pillar to develop miniaturized electrochemical biosensors for onsite and fast detection of nerve and mustard agents, allowing for a lab on a chip in the chemical warfare agent sector. In the fast growth of novel technologies, the combination of miniaturized electrochemical biosensors with flexible electronics allowed for the delivery of useful wearable sensors capable of fast detection of chemical warfare agents. The wearable microneedle sensor array for minimally invasive continuous electrochemical detection of organophosphorus nerve agents, as well as the wearable paper-based origami functionalized with nanomaterials for mustard agents in the gas phase, represent two examples of the forefront devices developed in the chemical warfare agent detection field. This review will highlight the most promising electrochemical biosensors developed by exploiting nanomaterials and cross-cutting technologies for the fabrication of smart and sensitive electrochemical biosensors for the detection of chemical warfare agents.