cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four major chronic non-communicable diseases (NCDs) representing the leading cause of death worldwide. Several studies demonstrate that endothelial dysfunction (ED) plays a central role in the pathogenesis of these chronic diseases. although it is well known that systemic chronic inflammation and oxidative stress are primarily involved in the development of ED, recent studies have shown that perivascular adipose tissue (PVAT) is implicated in its pathogenesis, also contributing to the progression of atherosclerosis and to insulin resistance (IR). In this review, we describe the relationship between PVAT and ED, and we also analyse the role of PVAT in the pathogenesis of CVDs and T2DM, further assessing its potential therapeutic target with the aim of restoring normal ED and reducing global cardiovascular risk.

Valentini, A., Cardillo, C., Della Morte, D., Tesauro, M. (2023). The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus. BIOMEDICINES, 11(11) [10.3390/biomedicines11113006].

The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus

Valentini, Alessia;Della Morte, David;Tesauro, Manfredi
2023-11-09

Abstract

cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four major chronic non-communicable diseases (NCDs) representing the leading cause of death worldwide. Several studies demonstrate that endothelial dysfunction (ED) plays a central role in the pathogenesis of these chronic diseases. although it is well known that systemic chronic inflammation and oxidative stress are primarily involved in the development of ED, recent studies have shown that perivascular adipose tissue (PVAT) is implicated in its pathogenesis, also contributing to the progression of atherosclerosis and to insulin resistance (IR). In this review, we describe the relationship between PVAT and ED, and we also analyse the role of PVAT in the pathogenesis of CVDs and T2DM, further assessing its potential therapeutic target with the aim of restoring normal ED and reducing global cardiovascular risk.
9-nov-2023
Pubblicato
Rilevanza internazionale
Review
Esperti anonimi
Settore MED/49
Settore MEDS-08/C - Scienza dell'alimentazione e delle tecniche dietetiche applicate
English
cardiovascular diseases (CVDs)
endothelial dysfunction (ED)
insulin resistance (IR)
non-communicable diseases (NCDs)
perivascular adipose tissue (PVAT)
type 2 diabetes mellitus (T2DM)
Valentini, A., Cardillo, C., Della Morte, D., Tesauro, M. (2023). The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus. BIOMEDICINES, 11(11) [10.3390/biomedicines11113006].
Valentini, A; Cardillo, C; Della Morte, D; Tesauro, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/388094
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