purpose orthostatic hypotension (OH) may predispose older adults to health complications leading to functional impairment. despite the central role of the kidney in blood pressure control, the contribution of renal function in orthostatic hypotension is poorly investigated. to verify the association between chronic kidney disease (CKD) and OH a population of hospitalised elderly patients with comorbidities was studied. materials and methods 174 patients were consecutively admitted to acute geriatric wards. on admission, patients underwent postural systolic (SBP) and diastolic (DBP) blood pressure evaluation by automatic oscillometric device after 10 min rest in lying position, and in standing position at time 0, 1, 3 and 5 min. CKD was assumed for estimated glomerular filtration rate (e-GFR) less than 60 mL/min/1.73 m(2). results the mean age of the population enrolled was 74.4 +/- 7.0. OH was found in 46.0% and CKD in 56.3% of patients, respectively. a lower e-GFR was observed in patients with (56.1 +/- 16.7 mL/min/1.73 m2) than in those without OH (61.1 +/- 15.9 mL/min/1.73 m(2)) (p < 0.05). a greater fall in SBP at 0-min (12.8 +/- 6.3 vs. 7.7 +/- 3.2 mmHg) and at 1-min (8.4 +/- 4.5 vs. 5.7 +/- 2.8 mmHg) was found in CKD patients in respect to patients without CKD during active standing test (p < 0.05). Similarly, a DBP reduction at 0-min and at 1-min was observed in CKD patients in respect to patients without CKD (p < 0.05). a multivariate logistic regression analysis showed that CKD was associated to OH (OR 2.426; 95%CI 1.192-4.937; p = 0.014). Conclusions CKD is associated to OH in hospitalised older adults.

Curcio, F., Chiappetti, R., De Furio, M., Flocco, V., Della Morte, D., Testa, G., et al. (2024). Chronic kidney disease and orthostatic hypotension in hospitalised older adults. BLOOD PRESSURE, 33(1) [10.1080/08037051.2024.2336243].

Chronic kidney disease and orthostatic hypotension in hospitalised older adults

Della Morte, David;
2024-12-01

Abstract

purpose orthostatic hypotension (OH) may predispose older adults to health complications leading to functional impairment. despite the central role of the kidney in blood pressure control, the contribution of renal function in orthostatic hypotension is poorly investigated. to verify the association between chronic kidney disease (CKD) and OH a population of hospitalised elderly patients with comorbidities was studied. materials and methods 174 patients were consecutively admitted to acute geriatric wards. on admission, patients underwent postural systolic (SBP) and diastolic (DBP) blood pressure evaluation by automatic oscillometric device after 10 min rest in lying position, and in standing position at time 0, 1, 3 and 5 min. CKD was assumed for estimated glomerular filtration rate (e-GFR) less than 60 mL/min/1.73 m(2). results the mean age of the population enrolled was 74.4 +/- 7.0. OH was found in 46.0% and CKD in 56.3% of patients, respectively. a lower e-GFR was observed in patients with (56.1 +/- 16.7 mL/min/1.73 m2) than in those without OH (61.1 +/- 15.9 mL/min/1.73 m(2)) (p < 0.05). a greater fall in SBP at 0-min (12.8 +/- 6.3 vs. 7.7 +/- 3.2 mmHg) and at 1-min (8.4 +/- 4.5 vs. 5.7 +/- 2.8 mmHg) was found in CKD patients in respect to patients without CKD during active standing test (p < 0.05). Similarly, a DBP reduction at 0-min and at 1-min was observed in CKD patients in respect to patients without CKD (p < 0.05). a multivariate logistic regression analysis showed that CKD was associated to OH (OR 2.426; 95%CI 1.192-4.937; p = 0.014). Conclusions CKD is associated to OH in hospitalised older adults.
dic-2024
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49
Settore MEDS-08/C - Scienza dell'alimentazione e delle tecniche dietetiche applicate
English
Orthostatic hypotension
chronic kidney disease
comorbidity
estimated glomerular filtration rate
older adults
Curcio, F., Chiappetti, R., De Furio, M., Flocco, V., Della Morte, D., Testa, G., et al. (2024). Chronic kidney disease and orthostatic hypotension in hospitalised older adults. BLOOD PRESSURE, 33(1) [10.1080/08037051.2024.2336243].
Curcio, F; Chiappetti, R; De Furio, M; Flocco, V; Della Morte, D; Testa, G; Gargiulo, G; Cacciatore, F; Abete, P; Galizia, G; Null, N
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/388081
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