We analyzed single nucleotide polymorphisms in the 5'-untranslated region (-44C/G and -52G/A) of the beta-defensin-1 gene in 78 Mozambican HIV-1-infected mothers. We observed significantly lower levels of HIV-1 RNA in breast milk, but not in plasma, in women with the -52GG genotype versus women with the -52GA and -52AA genotypes, supporting the hypothesis that different expression of beta-defensins could have an impact on viral replication in breast milk.

Baroncelli, S., Ricci, E., Andreotti, M., Guidotti, G., Germano, P., Marazzi, M., et al. (2008). Single-nucleotide polymorphisms in human beta-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters. AIDS, 22(12), 1515-1517 [10.1097/QAD.0b013e3282fd6e0c].

Single-nucleotide polymorphisms in human beta-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters

PALOMBI, LEONARDO;
2008-07-01

Abstract

We analyzed single nucleotide polymorphisms in the 5'-untranslated region (-44C/G and -52G/A) of the beta-defensin-1 gene in 78 Mozambican HIV-1-infected mothers. We observed significantly lower levels of HIV-1 RNA in breast milk, but not in plasma, in women with the -52GG genotype versus women with the -52GA and -52AA genotypes, supporting the hypothesis that different expression of beta-defensins could have an impact on viral replication in breast milk.
lug-2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/42 - IGIENE GENERALE E APPLICATA
English
Con Impact Factor ISI
beta defensin 1; beta defensin; DEFB1 protein, human; virus RNA; 5' untranslated region; article; breast milk; female; gene expression; genotype; highly active antiretroviral therapy; human; Human immunodeficiency virus 1; Human immunodeficiency virus 1 infection; Human immunodeficiency virus infected patient; mother; nonhuman; nucleotide sequence; plasma; priority journal; single nucleotide polymorphism; virus replication; genetic predisposition; genetics; Human immunodeficiency virus infection; isolation and purification; virology; virus load; Antiretroviral Therapy, Highly Active; beta-Defensins; Female; Genetic Predisposition to Disease; HIV Infections; HIV-1; Humans; Milk, Human; Polymorphism, Single Nucleotide; RNA, Viral; Viral Load
Baroncelli, S., Ricci, E., Andreotti, M., Guidotti, G., Germano, P., Marazzi, M., et al. (2008). Single-nucleotide polymorphisms in human beta-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters. AIDS, 22(12), 1515-1517 [10.1097/QAD.0b013e3282fd6e0c].
Baroncelli, S; Ricci, E; Andreotti, M; Guidotti, G; Germano, P; Marazzi, M; Vella, S; Palombi, L; De Rossi, A; Giuliano, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/38715
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