Background: The long-term prognosis of patients with colon cancer is dependent on many factors. To investigate the influence of a series of clinical, laboratory and morphological variables on prognosis of colon carcinoma we conducted a retrospective analysis of our data. Methods: Ninety-two patients with colon cancer, who underwent surgical resection between January 1999 and December 2001, were analyzed. On survival analysis, demographics, clinical, laboratory and pathomorphological parameters were tested for their potential prognostic value. Furthermore, univariate and multivariate analysis of the above mentioned data were performed considering the depth of tumour invasion into the bowel wall as independent variable. Results: On survival analysis we found that depth of tumour invasion (P < 0.001; F-ratio 2.11), type of operation (P < 0.001; F-ratio 3.51) and CT scanning (P < 0.001; F-ratio 5.21) were predictors of survival. Considering the degree of mural invasion as independent variable, on univariate analysis, we observed that mucorrhea, anismus, hematocrit, WBC count, fibrinogen value and CT scanning were significantly related to the degree of mural invasion of the cancer. On the multivariate analysis, fibrinogen value was the most statistically significant variable (P < 0.001) with the highest F-ratio (Fratio 5.86). Finally, in the present study, the tumour site was significantly related neither to the survival nor to the mural invasion of the tumour. Conclusion: The various clinical, laboratory and patho-morphological parameters showed different prognostic value for colon carcinoma. In the future, preoperative prognostic markers will probably gain relevance in order to make a proper choice between surgery, chemotherapy and radiotherapy. Nevertheless, current data do not provide sufficient evidence for preoperative stratification of high and low risk patients. Further assessments in prospective large studies are warranted.

Grande, M., Milito, G., Attina, G., Cadeddu, F., Gallinella Muzi, M., Nigro, C., et al. (2008). Evaluation of clinical, laboratory and morphologic prognostic factors in colon cancer. WORLD JOURNAL OF SURGICAL ONCOLOGY, 6, 98 [10.1186/1477-7819-6-98].

Evaluation of clinical, laboratory and morphologic prognostic factors in colon cancer

GRANDE, MICHELE;MILITO, GIOVANNI;CADEDDU, FEDERICA;GALLINELLA MUZI, MARCO;NIGRO, CASIMIRO;RULLI, FRANCESCO;FARINON, ATTILIO MARIA
2008

Abstract

Background: The long-term prognosis of patients with colon cancer is dependent on many factors. To investigate the influence of a series of clinical, laboratory and morphological variables on prognosis of colon carcinoma we conducted a retrospective analysis of our data. Methods: Ninety-two patients with colon cancer, who underwent surgical resection between January 1999 and December 2001, were analyzed. On survival analysis, demographics, clinical, laboratory and pathomorphological parameters were tested for their potential prognostic value. Furthermore, univariate and multivariate analysis of the above mentioned data were performed considering the depth of tumour invasion into the bowel wall as independent variable. Results: On survival analysis we found that depth of tumour invasion (P < 0.001; F-ratio 2.11), type of operation (P < 0.001; F-ratio 3.51) and CT scanning (P < 0.001; F-ratio 5.21) were predictors of survival. Considering the degree of mural invasion as independent variable, on univariate analysis, we observed that mucorrhea, anismus, hematocrit, WBC count, fibrinogen value and CT scanning were significantly related to the degree of mural invasion of the cancer. On the multivariate analysis, fibrinogen value was the most statistically significant variable (P < 0.001) with the highest F-ratio (Fratio 5.86). Finally, in the present study, the tumour site was significantly related neither to the survival nor to the mural invasion of the tumour. Conclusion: The various clinical, laboratory and patho-morphological parameters showed different prognostic value for colon carcinoma. In the future, preoperative prognostic markers will probably gain relevance in order to make a proper choice between surgery, chemotherapy and radiotherapy. Nevertheless, current data do not provide sufficient evidence for preoperative stratification of high and low risk patients. Further assessments in prospective large studies are warranted.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/18 - Chirurgia Generale
English
Con Impact Factor ISI
fibrinogen; adult; aged; article; cancer invasion; cancer surgery; cancer survival; colon carcinoma; computer assisted tomography; demography; female; hematocrit; human; leukocyte count; major clinical study; male; prognosis; retrospective study; surgical technique; colon tumor; middle aged; Adult; Aged; Aged, 80 and over; Colonic Neoplasms; Female; Humans; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Retrospective Studies
Grande, M., Milito, G., Attina, G., Cadeddu, F., Gallinella Muzi, M., Nigro, C., et al. (2008). Evaluation of clinical, laboratory and morphologic prognostic factors in colon cancer. WORLD JOURNAL OF SURGICAL ONCOLOGY, 6, 98 [10.1186/1477-7819-6-98].
Grande, M; Milito, G; Attina, Gm; Cadeddu, F; GALLINELLA MUZI, M; Nigro, C; Rulli, F; Farinon, Am
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/38487
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