The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.
Bernassola, F., Karin, M., Ciechanover, A., & Melino, G. (2008). The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development. CANCER CELL, 14(1), 10-21.
Tipologia: | Articolo su rivista |
Citazione: | Bernassola, F., Karin, M., Ciechanover, A., & Melino, G. (2008). The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development. CANCER CELL, 14(1), 10-21. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/11 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.ccr.2008.06.001 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2008 |
Titolo: | The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development |
Autori: | |
Autori: | Bernassola, F; Karin, M; Ciechanover, A; Melino, G. |
Appare nelle tipologie: | 01 - Articolo su rivista |