The haplotypes at four polymorphic loci of the Y chromosome were determined in 245 Caucasian males from 12 subpopulations. The data show that haplotype radiation occurred among Caucasians. Haplotype radiation was accompanied by recurrent mutations at STR loci that caused partial randomization of haplotype structure. The present distribution of alleles at short tandem repeats (STRs) can be explained by a mutation pattern similar to those described for autosomal STRs. The degree of variation among groups of subpopulations was assayed by using the Analysis of Molecular Variance. The results confirm a faster divergence of the Y chromosome as compared to the rest of the genome.
Ciminelli, B.m., Pompei, F., Malaspina, P., Hammer, M., Persichetti, F., Pignatti, P., et al. (1995). Recurrent simple tandem repeat mutations during human Y-chromosome radiation in Caucasian subpopulations. JOURNAL OF MOLECULAR EVOLUTION, 41(6), 966-973 [10.1007/BF00173177].
Recurrent simple tandem repeat mutations during human Y-chromosome radiation in Caucasian subpopulations
CIMINELLI, BIANCA MARIA;MALASPINA, PATRIZIA;IODICE, CARLA;TERRENATO, LUCIANO;NOVELLETTO, ANDREA
1995-01-01
Abstract
The haplotypes at four polymorphic loci of the Y chromosome were determined in 245 Caucasian males from 12 subpopulations. The data show that haplotype radiation occurred among Caucasians. Haplotype radiation was accompanied by recurrent mutations at STR loci that caused partial randomization of haplotype structure. The present distribution of alleles at short tandem repeats (STRs) can be explained by a mutation pattern similar to those described for autosomal STRs. The degree of variation among groups of subpopulations was assayed by using the Analysis of Molecular Variance. The results confirm a faster divergence of the Y chromosome as compared to the rest of the genome.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
