author summary center dot Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that may be less effective, less well-tolerated, and more expensive than those used in first-line regimens.center dot HIV drug resistance studies are designed to determine which HIV mutations are selected by antiretroviral drugs and, in turn, how these mutations affect antiretroviral drug susceptibility and response to future antiretroviral treatment regimens.center dot such studies collectively form a vital knowledge base essential for monitoring global HIV drug resistance trends, interpreting HIV genotypic tests, and updating HIV treatment guidelines.center dot although HIV drug resistance data are collected in many studies, such data are often not publicly shared, prompting the need to recommend best practices to encourage and standardize HIV drug resistance data sharing.center dot In contrast to other viruses, sharing HIV sequences from phylogenetic studies of transmission dynamics requires additional precautions as HIV transmission is criminalized in many countries and regions.center dot our recommendations are designed to ensure that the data that contribute to HIV drug resistance knowledge will be available without undue hardship to those publishing HIV drug resistance studies and without risk to people living with HIV.

Inzaule, S.c., Siedner, M.j., Little, S.j., Avila-Rios, S., Ayitewala, A., Bosch, R.j., et al. (2023). Recommendations on data sharing in HIV drug resistance research. PLOS MEDICINE, 20(9), 1-9 [10.1371/journal.pmed.1004293].

Recommendations on data sharing in HIV drug resistance research

Ceccherini-Silberstein, Francesca;
2023-09-01

Abstract

author summary center dot Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that may be less effective, less well-tolerated, and more expensive than those used in first-line regimens.center dot HIV drug resistance studies are designed to determine which HIV mutations are selected by antiretroviral drugs and, in turn, how these mutations affect antiretroviral drug susceptibility and response to future antiretroviral treatment regimens.center dot such studies collectively form a vital knowledge base essential for monitoring global HIV drug resistance trends, interpreting HIV genotypic tests, and updating HIV treatment guidelines.center dot although HIV drug resistance data are collected in many studies, such data are often not publicly shared, prompting the need to recommend best practices to encourage and standardize HIV drug resistance data sharing.center dot In contrast to other viruses, sharing HIV sequences from phylogenetic studies of transmission dynamics requires additional precautions as HIV transmission is criminalized in many countries and regions.center dot our recommendations are designed to ensure that the data that contribute to HIV drug resistance knowledge will be available without undue hardship to those publishing HIV drug resistance studies and without risk to people living with HIV.
set-2023
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07
Settore MEDS-03/A - Microbiologia e microbiologia clinica
English
Inzaule, S.c., Siedner, M.j., Little, S.j., Avila-Rios, S., Ayitewala, A., Bosch, R.j., et al. (2023). Recommendations on data sharing in HIV drug resistance research. PLOS MEDICINE, 20(9), 1-9 [10.1371/journal.pmed.1004293].
Inzaule, Sc; Siedner, Mj; Little, Sj; Avila-Rios, S; Ayitewala, A; Bosch, Rj; Calvez, V; Ceccherini-Silberstein, F; Charpentier, C; Descamps, D; Eshle...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/381525
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