Adipose tissue-derived stem cells (ADSCs) represent a subset of the mesenchymal stem cells in every adipose compartment throughout the body. ADSCs can differentiate into various cell types, including chondrocytes, osteocytes, myocytes, and adipocytes. Moreover, they exhibit a notable potential to differentiate in vitro into cells from other germinal lineages, including endothelial cells and neurons. ADSCs have a wide range of clinical applications, from breast surgery to chronic wounds. Furthermore, they are a promising cell population for future tissue-engineering uses. Accumulating evidence indicates a decreased proliferation and differentiation potential of ADSCs with an increasing age, increasing body mass index, diabetes mellitus, metabolic syndrome, or exposure to radiotherapy. Therefore, the recent literature thoroughly investigates this cell population's senescence mechanisms and how they can hinder its possible therapeutic applications. This review will discuss the biological mechanisms and the physio-pathological causes behind ADSC senescence and how they can impact cellular functionality. Moreover, we will examine the possible strategies to invert these processes, re-establishing the full regenerative potential of this progenitor population.

Foti, R., Storti, G., Palmesano, M., Scioli, M.g., Fiorelli, E., Terriaca, S., et al. (2024). Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(15), 1-22 [10.3390/ijms25158390].

Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges

Riccardo Foti;Gabriele Storti
;
Marco Palmesano;Maria Giovanna Scioli;Elena Fiorelli;Sonia Terriaca;Giulio Cervelli;augusto orlandi;Valerio Cervelli
2024-08-01

Abstract

Adipose tissue-derived stem cells (ADSCs) represent a subset of the mesenchymal stem cells in every adipose compartment throughout the body. ADSCs can differentiate into various cell types, including chondrocytes, osteocytes, myocytes, and adipocytes. Moreover, they exhibit a notable potential to differentiate in vitro into cells from other germinal lineages, including endothelial cells and neurons. ADSCs have a wide range of clinical applications, from breast surgery to chronic wounds. Furthermore, they are a promising cell population for future tissue-engineering uses. Accumulating evidence indicates a decreased proliferation and differentiation potential of ADSCs with an increasing age, increasing body mass index, diabetes mellitus, metabolic syndrome, or exposure to radiotherapy. Therefore, the recent literature thoroughly investigates this cell population's senescence mechanisms and how they can hinder its possible therapeutic applications. This review will discuss the biological mechanisms and the physio-pathological causes behind ADSC senescence and how they can impact cellular functionality. Moreover, we will examine the possible strategies to invert these processes, re-establishing the full regenerative potential of this progenitor population.
1-ago-2024
Pubblicato
Rilevanza internazionale
Review
Sì, ma tipo non specificato
Settore MED/19
Settore MED/08
Settore BIO/13
Settore MED/46
Settore MED/50
English
adipose-derived stem cells
ageing
diabetes
mesenchymal stem cells
senescence
senolytic drugs
stem cell therapy
Foti, R., Storti, G., Palmesano, M., Scioli, M.g., Fiorelli, E., Terriaca, S., et al. (2024). Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(15), 1-22 [10.3390/ijms25158390].
Foti, R; Storti, G; Palmesano, M; Scioli, Mg; Fiorelli, E; Terriaca, S; Cervelli, G; Sung Kim, B; Orlandi, A; Cervelli, V
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/380903
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