Programmed cell death is an orchestrated form of cell death in which cells are actively involved in their own demise. During neural development in mammals, many progenitor cells, immature cells or differentiated cells undergo the most clearly characterized type of cell death, apoptosis. Several pathways of apoptosis have been linked to neural development, but according to the numerous and striking phenotypes observed when apoptotic genes are inactivated, the mitochondrial death-route is the most important pathway in this context. Here, we discuss the relative importance of pro-growth/pro-death factors in the control of neural tissue development. We also discuss the impact of studying programmed cell death in development in order to better understand the basis of several human diseases and embryonic defects of the nervous system. © 2004 Elsevier Ltd. All rights reserved.

De Zio D., G.L. (2005). Expanding roles of programmed cell death in mammalian neurodevelopment. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 16(2), 281-294 [10.1016/j.semcdb.2004.12.003].

Expanding roles of programmed cell death in mammalian neurodevelopment

CECCONI, FRANCESCO
2005

Abstract

Programmed cell death is an orchestrated form of cell death in which cells are actively involved in their own demise. During neural development in mammals, many progenitor cells, immature cells or differentiated cells undergo the most clearly characterized type of cell death, apoptosis. Several pathways of apoptosis have been linked to neural development, but according to the numerous and striking phenotypes observed when apoptotic genes are inactivated, the mitochondrial death-route is the most important pathway in this context. Here, we discuss the relative importance of pro-growth/pro-death factors in the control of neural tissue development. We also discuss the impact of studying programmed cell death in development in order to better understand the basis of several human diseases and embryonic defects of the nervous system. © 2004 Elsevier Ltd. All rights reserved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/06
English
Con Impact Factor ISI
Apoptosome; Caspases; Embryonic cancer; Knockout; Neural precursor
De Zio D., G.L. (2005). Expanding roles of programmed cell death in mammalian neurodevelopment. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 16(2), 281-294 [10.1016/j.semcdb.2004.12.003].
De Zio, D; Giunta, L; Corvaro, M; Ferraro, E; Cecconi, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/37942
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