Atherosclerosis is a chronic inflammatory disease characterized by lipid and inflammatory cell deposits in the inner layer of large- and medium-sized elastic and muscular arteries. Diabetes mellitus (DM) significantly increases the risk of cardiovascular diseases and the overall and cardiovascular mortality, and it is a pro-atherogenic factor that induces atherosclerosis development and/or accelerates its progression through a multifactorial process. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a new class of drugs, belonging to the armamentarium to fight type 2 DM, that have shown robust reductions in atherosclerotic events and all-cause mortality in all studies. Preclinical studies have shown that GLP-1RAs play a role in the immunomodulation of atherosclerosis, affecting multiple pathways involved in plaque development and progression. In this review, we wanted to explore the translational power of such preclinical studies by analyzing the most recent clinical trials investigating the atheroprotective effect of GLP-1RAs.

Lecis, D., Prandi, F.r., Barone, L., Belli, M., Sergi, D., Longo, S., et al. (2023). Beyond the Cardiovascular Effects of Glucagon-like Peptide-1 Receptor Agonists: Body Slimming and Plaque Stabilization. Are New Statins Born?. BIOMOLECULES, 13(12), 1-13 [10.3390/biom13121695].

Beyond the Cardiovascular Effects of Glucagon-like Peptide-1 Receptor Agonists: Body Slimming and Plaque Stabilization. Are New Statins Born?

Lecis, Dalgisio;Prandi, Francesca Romana;Barone, Lucy;Belli, Martina;Sergi, Domenico;Longo, Susanna;Muscoli, Saverio;Romeo, Francesco;Federici, Massimo;
2023-11-23

Abstract

Atherosclerosis is a chronic inflammatory disease characterized by lipid and inflammatory cell deposits in the inner layer of large- and medium-sized elastic and muscular arteries. Diabetes mellitus (DM) significantly increases the risk of cardiovascular diseases and the overall and cardiovascular mortality, and it is a pro-atherogenic factor that induces atherosclerosis development and/or accelerates its progression through a multifactorial process. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a new class of drugs, belonging to the armamentarium to fight type 2 DM, that have shown robust reductions in atherosclerotic events and all-cause mortality in all studies. Preclinical studies have shown that GLP-1RAs play a role in the immunomodulation of atherosclerosis, affecting multiple pathways involved in plaque development and progression. In this review, we wanted to explore the translational power of such preclinical studies by analyzing the most recent clinical trials investigating the atheroprotective effect of GLP-1RAs.
23-nov-2023
Pubblicato
Rilevanza internazionale
Review
Esperti anonimi
Settore MED/09
English
GLP-1RAs
atherosclerosis
cardiovascular disease
diabetes mellitus
prevention
Lecis, D., Prandi, F.r., Barone, L., Belli, M., Sergi, D., Longo, S., et al. (2023). Beyond the Cardiovascular Effects of Glucagon-like Peptide-1 Receptor Agonists: Body Slimming and Plaque Stabilization. Are New Statins Born?. BIOMOLECULES, 13(12), 1-13 [10.3390/biom13121695].
Lecis, D; Prandi, Fr; Barone, L; Belli, M; Sergi, D; Longo, S; Muscoli, S; Romeo, F; Federici, M; Lerakis, S; Barillà, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/379323
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