The Prevalence of Benzodiazepine Use among Italian Drivers in 15,988 Cases of Driving License Regranting from 2015 to 2023: Risks and Implications for Driving Fitness

The use of benzodiazepines is strongly associated with an increased risk of traffic accidents due to their side effects of sedation and drowsiness, which can significantly impair driving performance. the main aim of our study was to investigate the trend of benzodiazepine use over nine years (2015-2023) in a population of 15,988 subjects who had their license suspended for driving under the influence (DUI) of alcohol or drugs. among the 15,988 users accessed to our laboratory, 924 tested positive for at least one benzodiazepine. an increase in the number of positive-testing users was observed in the period 2015-2018, followed by a slight decrease in 2019. overall, the trend of benzodiazepine use was stable over the next four years (2020-2023), with the highest incidence in 2022. the most common benzodiazepines, and/or metabolites, found in urine samples were alpha-OH-alprazolam (28.66%; n = 366) and oxazepam (27.25%; n = 348). Several cases of mixed positivity were observed in the study population. the main substances taken with benzodiazepines were cocaine and Delta 9-tetrahydrocannabinol. Our findings suggest that people taking benzodiazepines should be monitored, as these have a relevant impact on driving ability in addition to significant interindividual differences in the behavioral effects of benzodiazepines on driving performance.