We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formomide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide.

Saladino, R., Crestini, C., Neri, V., Brucato, J., Colangeli, L., Ciciriello, F., et al. (2005). Synthesis and degradation of nucleic acid components by formamide and cosmic dust analogues. CHEMBIOCHEM, 6(8), 1368-1374 [10.1002/cbic.200500035].

Synthesis and degradation of nucleic acid components by formamide and cosmic dust analogues

CRESTINI, CLAUDIA;
2005-01-01

Abstract

We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formomide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide.
2005
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore CHIM/03 - CHIMICA GENERALE E INORGANICA
English
Con Impact Factor ISI
Cosmic-dust analogues; Nucleic acids; Nucleobases; Oligonucleotides; Pyrimidines
Saladino, R., Crestini, C., Neri, V., Brucato, J., Colangeli, L., Ciciriello, F., et al. (2005). Synthesis and degradation of nucleic acid components by formamide and cosmic dust analogues. CHEMBIOCHEM, 6(8), 1368-1374 [10.1002/cbic.200500035].
Saladino, R; Crestini, C; Neri, V; Brucato, J; Colangeli, L; Ciciriello, F; Di Mauro, E; Costanzo, G
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/37518
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