a growing number of clinical trials are documenting that adding a long-acting muscarinic antagonist (LAMA) to established asthma treatment with an inhaled corticosteroid (ICS) and a long-acting beta(2)-agonist (LABA) is a treatment option that improves the health of patients with uncontrolled severe asthma even when therapy is optimized. These favorable results are the reason why the leading guidelines recommend triple therapy with ICS + LABA + LAMA in patients with asthma uncontrolled by medium- to high-dose ICS-LABA. However, we suggest adding LAMAs to ICS-LABAs at an earlier clinical stage. such action could positively influence airflow limitation, exacerbations, and eosinophilic inflammation, conditions that are associated with acetylcholine (ACh) activity. It could also interrupt the vicious cycle related to a continuous release of ACh leading to the progressive expansion of neuronal plasticity resulting in small airway dysfunction. the utility of an earlier use of triple therapy in asthma should, in any case, be confirmed by statistically powered trials.

Cazzola, M., Rogliani, P., Matera, M.g. (2023). Might It Be Appropriate to Anticipate the Use of Long-Acting Muscarinic Antagonists in Asthma?. DRUGS, 83(11), 957-965 [10.1007/s40265-023-01897-2].

Might It Be Appropriate to Anticipate the Use of Long-Acting Muscarinic Antagonists in Asthma?

Cazzola M.;Rogliani P.;Matera M. G.
2023-01-01

Abstract

a growing number of clinical trials are documenting that adding a long-acting muscarinic antagonist (LAMA) to established asthma treatment with an inhaled corticosteroid (ICS) and a long-acting beta(2)-agonist (LABA) is a treatment option that improves the health of patients with uncontrolled severe asthma even when therapy is optimized. These favorable results are the reason why the leading guidelines recommend triple therapy with ICS + LABA + LAMA in patients with asthma uncontrolled by medium- to high-dose ICS-LABA. However, we suggest adding LAMAs to ICS-LABAs at an earlier clinical stage. such action could positively influence airflow limitation, exacerbations, and eosinophilic inflammation, conditions that are associated with acetylcholine (ACh) activity. It could also interrupt the vicious cycle related to a continuous release of ACh leading to the progressive expansion of neuronal plasticity resulting in small airway dysfunction. the utility of an earlier use of triple therapy in asthma should, in any case, be confirmed by statistically powered trials.
2023
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/10
Settore MEDS-07/A - Malattie dell'apparato respiratorio
English
Cazzola, M., Rogliani, P., Matera, M.g. (2023). Might It Be Appropriate to Anticipate the Use of Long-Acting Muscarinic Antagonists in Asthma?. DRUGS, 83(11), 957-965 [10.1007/s40265-023-01897-2].
Cazzola, M; Rogliani, P; Matera, Mg
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/374249
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