To survive, an informational macromolecule must solve the major problem set by its very polymeric nature: instability. This is especially true in prebiotic terms because of the presumed initial absence of protective structures (proteins, lipids, etc.). We have analyzed the stability of the β-glycosidic and of the 3′- and 5′-phosphoester bonds in both deoxy monomers and deoxy oligomers under a large set of conditions. The results show a strong dependence of the relative stability of these bonds on the physico-chemical environment. A set of conditions has been identified in which the stability of polymers becomes comparable with that of the precursor monomers. In certain instances the stability of the 5′-phosphoester bond is even higher in the polymer than in the mononucleotide. © 2005 by The American Society for Biochemistry and Molecular Biology, Inc.
Saladino, R., Crestini, C., Busiello, V., Ciciriello, F., Costanzo, G., & Di Mauro, E. (2005). Origin of informational polymers: Differential stability of 3′-and 5′-phosphoester bonds in deoxy monomers and oligomers. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 280(42), 35658-35669.
Tipologia: | Articolo su rivista |
Citazione: | Saladino, R., Crestini, C., Busiello, V., Ciciriello, F., Costanzo, G., & Di Mauro, E. (2005). Origin of informational polymers: Differential stability of 3′-and 5′-phosphoester bonds in deoxy monomers and oligomers. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 280(42), 35658-35669. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore CHIM/03 - Chimica Generale e Inorganica |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1074/jbc.M504537200 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2005 |
Titolo: | Origin of informational polymers: Differential stability of 3′-and 5′-phosphoester bonds in deoxy monomers and oligomers |
Autori: | |
Autori: | Saladino, R ; Crestini, C ; Busiello, V ; Ciciriello, F ; Costanzo, G ; Di Mauro, E |
Appare nelle tipologie: | 01 - Articolo su rivista |