To survive, an informational macromolecule must solve the major problem set by its very polymeric nature: instability. This is especially true in prebiotic terms because of the presumed initial absence of protective structures (proteins, lipids, etc.). We have analyzed the stability of the β-glycosidic and of the 3′- and 5′-phosphoester bonds in both deoxy monomers and deoxy oligomers under a large set of conditions. The results show a strong dependence of the relative stability of these bonds on the physico-chemical environment. A set of conditions has been identified in which the stability of polymers becomes comparable with that of the precursor monomers. In certain instances the stability of the 5′-phosphoester bond is even higher in the polymer than in the mononucleotide. © 2005 by The American Society for Biochemistry and Molecular Biology, Inc.

Saladino, R., Crestini, C., Busiello, V., Ciciriello, F., Costanzo, G., & Di Mauro, E. (2005). Origin of informational polymers: Differential stability of 3′-and 5′-phosphoester bonds in deoxy monomers and oligomers. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 280(42), 35658-35669 [10.1074/jbc.M504537200].

Origin of informational polymers: Differential stability of 3′-and 5′-phosphoester bonds in deoxy monomers and oligomers

CRESTINI, CLAUDIA;
2005

Abstract

To survive, an informational macromolecule must solve the major problem set by its very polymeric nature: instability. This is especially true in prebiotic terms because of the presumed initial absence of protective structures (proteins, lipids, etc.). We have analyzed the stability of the β-glycosidic and of the 3′- and 5′-phosphoester bonds in both deoxy monomers and deoxy oligomers under a large set of conditions. The results show a strong dependence of the relative stability of these bonds on the physico-chemical environment. A set of conditions has been identified in which the stability of polymers becomes comparable with that of the precursor monomers. In certain instances the stability of the 5′-phosphoester bond is even higher in the polymer than in the mononucleotide. © 2005 by The American Society for Biochemistry and Molecular Biology, Inc.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore CHIM/03 - Chimica Generale e Inorganica
English
Con Impact Factor ISI
Biochemistry; Chemical bonds; Esters; Macromolecules; Monomers; Oligomers; Deoxy oligomers; Informational polymers; Mononucleotide; Phosphoester bonds; Functional polymers; deoxyribonucleotide; formamide; lipid; monomer; nucleic acid; nucleotide; oligomer; oligonucleotide; organophosphate; polymer; prebiotic agent; protein; water; 3' phosphoester bond; 5' phosphoester bond; article; chemical bond; degradation; elution; high performance liquid chromatography; macromolecule; physical chemistry; priority journal; survival; temperature dependence; Base Sequence; Biotechnology; Catalysis; Chromatography, High Pressure Liquid; Deoxyadenosines; DNA; Esters; Formamides; Glycosides; Kinetics; Lipids; Macromolecular Substances; Models, Chemical; Molecular Sequence Data; Molecular Structure; Nucleotides; Oligonucleotides; Polymers; RNA; Temperature; Time Factors
Saladino, R., Crestini, C., Busiello, V., Ciciriello, F., Costanzo, G., & Di Mauro, E. (2005). Origin of informational polymers: Differential stability of 3′-and 5′-phosphoester bonds in deoxy monomers and oligomers. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 280(42), 35658-35669 [10.1074/jbc.M504537200].
Saladino, R; Crestini, C; Busiello, V; Ciciriello, F; Costanzo, G; Di Mauro, E
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/37195
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