Narcolepsy, a neurologic disorder that leads to excessive daytime sleepiness, may represent a rare consequence of neoplastic lesions involving the sellar/parasellar and hypothalamic regions, the anatomical areas responsible for wakefulness. Optic pathway gliomas represent the most common neoplasm of these regions and present an excellent overall survival, while long-term neurologic impairments, such as visual loss, endocrinopathies, or sleep disorders, are the principal causes of morbidity. In this case report, we describe a non-NF1 patient suffering from a very extensive optical pathway glioma, who several years after the diagnosis in a radiological condition of stable disease, presented with severe narcolepsy, a rare complication, that led to the death of the patient.

Laus, B., Caroleo, A.m., Colafati, G.s., Carai, A., Moavero, R., Ferilli, M., et al. (2022). Secondary Narcolepsy as Worsening Sign in a Pediatric Case of Optic Pathway Glioma. CHILDREN, 9(10), 1-9 [10.3390/children9101455].

Secondary Narcolepsy as Worsening Sign in a Pediatric Case of Optic Pathway Glioma

Moavero, Romina;Valeriani, Massimiliano;
2022-09-23

Abstract

Narcolepsy, a neurologic disorder that leads to excessive daytime sleepiness, may represent a rare consequence of neoplastic lesions involving the sellar/parasellar and hypothalamic regions, the anatomical areas responsible for wakefulness. Optic pathway gliomas represent the most common neoplasm of these regions and present an excellent overall survival, while long-term neurologic impairments, such as visual loss, endocrinopathies, or sleep disorders, are the principal causes of morbidity. In this case report, we describe a non-NF1 patient suffering from a very extensive optical pathway glioma, who several years after the diagnosis in a radiological condition of stable disease, presented with severe narcolepsy, a rare complication, that led to the death of the patient.
23-set-2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/39
English
brain tumor
hypersomnia
low-grade gliomas
neurological sequelae
optic pathway glioma
pediatric case report
Laus, B., Caroleo, A.m., Colafati, G.s., Carai, A., Moavero, R., Ferilli, M., et al. (2022). Secondary Narcolepsy as Worsening Sign in a Pediatric Case of Optic Pathway Glioma. CHILDREN, 9(10), 1-9 [10.3390/children9101455].
Laus, B; Caroleo, Am; Colafati, Gs; Carai, A; Moavero, R; Ferilli, Man; Valeriani, M; Mastronuzzi, A; Cacchione, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/371252
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