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EnglishAge-related cardiac remodeling is characterized by changes in myocardial structure, which include fibrosis (ie, increased collagen concentration). The pathogenetic mechanisms of age-related cardiac changes and possible pharmacologic interventions are still a matter of investigation. A morphometric analysis of collagen accumulation was performed in Sirius Red-stained left ventricular sections of 3-month-old and 5-6-year-old animals after a 9-month period of propionyl-L-camitine treatment (PLC; 120 mg Kg(-1) day(-1) per os); aged rabbits showed decreased interstitial collagen accumulation and no changes in cellularity and apoptotic rate compared to controls. Age-related expression of vascular cell adhesion molecule-1 (VCAM-1)-positive microvessels was also reduced in PLC-treated rabbits. In vitro, the 16-hour, 10-mu M PLC treatment reduced collagen type I and VCAM-1 transcripts, which were investigated by reverse transcription-polymerase chain reaction, more markedly in cardiac fibroblasts from aged donors. In the latter, the anti-VCAM- 1 antibody treatment was found to be associated with a reduction in collagen type I transcripts. Our results demonstrated that long-term PLC treatment partially prevents age-related interstitial remodeling and suggests that a more complex interstitial cell-to-cell signaling regulates senescent myocardium properties.
| Tipologia: | Articolo su rivista |
| Citazione: | Orlandi, A., Francesconi, A., Ferlosio, A., Lascio, A., Marcellini, M., Pisano, C., et al. (2007). Propionyl-L-carnitine prevents age-related myocardial remodeling in the rabbit. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 50(2), 168-175. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/08 - Anatomia Patologica |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | 10.1097/FJC.0b013e31805d8ee9 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 2007 |
| Titolo: | Propionyl-L-carnitine prevents age-related myocardial remodeling in the rabbit |
| Autori: | |
| Autori: | Orlandi, A; Francesconi, A; Ferlosio, A; Lascio, A; Marcellini, M; Pisano, C; Spagnoli, Lg |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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