The aim of this study was to model the cerebral generators following painful electrical stimulation of the sigmoid colon in 10 healthy controls and 10 patients with visceral pain due to the irritable bowel syndrome. The evoked brain potentials to 30 painful electrical stimuli from the sigmoid colon were recorded from 31 surface electrodes and subjected to electrical dipole source modelling. Two dipoles in the bilateral insular cortex, one dipole in the anterior cingulate gyrus and two dipoles in the bilateral second somatosensory area were found. The anterior cingulate dipole showed a more posterior position in patients than in control subjects. This finding suggests that the cortical representation of painful stimuli can be modified in presence of chronic visceral pain and that this change involves the anterior cingulate gyrus. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

Drewes, A.m., Rössel, P., Le Pera, D., Arendt-Nielsen, L., Valeriani, M. (2005). Cortical neuroplastic changes to painful colon stimulation in patients with irritable bowel syndrome. NEUROSCIENCE LETTERS, 375(3), 157-161 [10.1016/j.neulet.2004.11.011].

Cortical neuroplastic changes to painful colon stimulation in patients with irritable bowel syndrome

Valeriani, Massimiliano
2005-03-03

Abstract

The aim of this study was to model the cerebral generators following painful electrical stimulation of the sigmoid colon in 10 healthy controls and 10 patients with visceral pain due to the irritable bowel syndrome. The evoked brain potentials to 30 painful electrical stimuli from the sigmoid colon were recorded from 31 surface electrodes and subjected to electrical dipole source modelling. Two dipoles in the bilateral insular cortex, one dipole in the anterior cingulate gyrus and two dipoles in the bilateral second somatosensory area were found. The anterior cingulate dipole showed a more posterior position in patients than in control subjects. This finding suggests that the cortical representation of painful stimuli can be modified in presence of chronic visceral pain and that this change involves the anterior cingulate gyrus. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
3-mar-2005
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/39
English
experimental pain
gut
irritable bowel syndrome
cortical reorganisation
source localisation
cingulate cortex
Drewes, A.m., Rössel, P., Le Pera, D., Arendt-Nielsen, L., Valeriani, M. (2005). Cortical neuroplastic changes to painful colon stimulation in patients with irritable bowel syndrome. NEUROSCIENCE LETTERS, 375(3), 157-161 [10.1016/j.neulet.2004.11.011].
Drewes, Am; Rössel, P; Le Pera, D; Arendt-Nielsen, L; Valeriani, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/368783
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