in our study, preparation of voluntary movement was used to physiologically activate the motor cortex areas and the effect of this activation on CO2 laser-evoked potentials (LEPs) was explored. LEPs were recorded from 31 scalp electrodes in 10 healthy subjects after painful stimulation of the right C6-C7 skin dermatomes. LEP stimuli were delivered in the time interval between a visual warning stimulus followed after 1 s. by an imperative stimulus. the imperative stimulus triggered: (i) no task in the baseline condition (pain); (ii) flexion-extension movements of the second finger of the right hand in the movement condition (pain + movement); (iii) cognitive task (mathematic computation) in the distraction condition (pain + cognition). the experimental conditions were also repeated during application of laser stimuli on the left C6-C7 skin dermatomes. compared with the baseline condition (no task required), during preparation of right-hand voluntary movement there was a significant reduction in LEP amplitude and subjective pain rating after right- but not after left-hand stimulation, which suggests that the observed effect cannot be attributed to a nonspecific reduction in attention toward painful stimulus. during preparation of a cognitive task, LEP amplitude was reduced compared to baseline. our results represent the first neurophysiological suggestion that physiological activation of the motor cortex, occurring during movement preparation, inhibits cortical pain processing by a centrifugal mechanism.

Le Pera, D., Brancucci, A., De Armas, L., Del Percio, C., Miliucci, R., Babiloni, C., et al. (2007). Inhibitory effect of voluntary movement preparation on cutaneous heat pain and laser‐evoked potentials. EUROPEAN JOURNAL OF NEUROSCIENCE, 25(6), 1900-1907 [10.1111/j.1460-9568.2007.05389.x].

Inhibitory effect of voluntary movement preparation on cutaneous heat pain and laser‐evoked potentials

Valeriani, M.
2007-01-01

Abstract

in our study, preparation of voluntary movement was used to physiologically activate the motor cortex areas and the effect of this activation on CO2 laser-evoked potentials (LEPs) was explored. LEPs were recorded from 31 scalp electrodes in 10 healthy subjects after painful stimulation of the right C6-C7 skin dermatomes. LEP stimuli were delivered in the time interval between a visual warning stimulus followed after 1 s. by an imperative stimulus. the imperative stimulus triggered: (i) no task in the baseline condition (pain); (ii) flexion-extension movements of the second finger of the right hand in the movement condition (pain + movement); (iii) cognitive task (mathematic computation) in the distraction condition (pain + cognition). the experimental conditions were also repeated during application of laser stimuli on the left C6-C7 skin dermatomes. compared with the baseline condition (no task required), during preparation of right-hand voluntary movement there was a significant reduction in LEP amplitude and subjective pain rating after right- but not after left-hand stimulation, which suggests that the observed effect cannot be attributed to a nonspecific reduction in attention toward painful stimulus. during preparation of a cognitive task, LEP amplitude was reduced compared to baseline. our results represent the first neurophysiological suggestion that physiological activation of the motor cortex, occurring during movement preparation, inhibits cortical pain processing by a centrifugal mechanism.
2007
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/39
English
CNV
cutaneous pain
laser evoked potential
motor programming
pain-motor interaction
Le Pera, D., Brancucci, A., De Armas, L., Del Percio, C., Miliucci, R., Babiloni, C., et al. (2007). Inhibitory effect of voluntary movement preparation on cutaneous heat pain and laser‐evoked potentials. EUROPEAN JOURNAL OF NEUROSCIENCE, 25(6), 1900-1907 [10.1111/j.1460-9568.2007.05389.x].
Le Pera, D; Brancucci, A; De Armas, L; Del Percio, C; Miliucci, R; Babiloni, C; Restuccia, D; Rossini, Pm; Valeriani, M
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
Eur J of Neuroscience - 2007 - Le Pera - Inhibitory effect of voluntary movement preparation on cutaneous heat pain and.pdf

solo utenti autorizzati

Tipologia: Versione Editoriale (PDF)
Licenza: Copyright dell'editore
Dimensione 730.36 kB
Formato Adobe PDF
730.36 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/368065
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 38
  • ???jsp.display-item.citation.isi??? 36
social impact