Objective: to investigate the presence of multiple spinothalamic pathways for warmth in the human spinal cord. Methods: laser evoked potentials to C-fiber stimulation (C-LEPs) were recorded in 15 healthy subjects after warmth stimulation of the dorsal midline at C5, T2, T6, and T10 vertebral levels. This method allowed us to calculate the spinal conduction velocity (CV) in two different ways: (1) the reciprocal of the slope of the regression line was obtained from the latencies of the different C-LEP components, and (2) the distance between C5 and T10 was divided by the latency difference of the responses at the two sites. In particular, we considered the C-N1 potential, generated in the second somatosensory (SII) area, and the late C-P2 response, generated in the anterior cingulate cortex (ACC). Results: the calculated CV of the spinal fibers generating the C-N1 potential (around 2.5 m/s) was significantly different (p < 0.01) from the one of the pathway producing the P2 response (around 1.4 m/s). Conclusions: our results suggest that the C-N1 and the C-P2 components are generated by two parallel spinal pathways. Significance: warmth sensation is subserved by parallel spinothalamic pathways, one probably reaching the SII area, the other the ACC

Valeriani, M., Pazzaglia, C., Ferraro, D., Virdis, D., Rotellini, S., Le Pera, D., et al. (2011). Evidence of different spinal pathways for the warmth evoked potentials. CLINICAL NEUROPHYSIOLOGY, 122(12), 2469-2474 [10.1016/j.clinph.2011.04.023].

Evidence of different spinal pathways for the warmth evoked potentials

Valeriani, M.;
2011-12-01

Abstract

Objective: to investigate the presence of multiple spinothalamic pathways for warmth in the human spinal cord. Methods: laser evoked potentials to C-fiber stimulation (C-LEPs) were recorded in 15 healthy subjects after warmth stimulation of the dorsal midline at C5, T2, T6, and T10 vertebral levels. This method allowed us to calculate the spinal conduction velocity (CV) in two different ways: (1) the reciprocal of the slope of the regression line was obtained from the latencies of the different C-LEP components, and (2) the distance between C5 and T10 was divided by the latency difference of the responses at the two sites. In particular, we considered the C-N1 potential, generated in the second somatosensory (SII) area, and the late C-P2 response, generated in the anterior cingulate cortex (ACC). Results: the calculated CV of the spinal fibers generating the C-N1 potential (around 2.5 m/s) was significantly different (p < 0.01) from the one of the pathway producing the P2 response (around 1.4 m/s). Conclusions: our results suggest that the C-N1 and the C-P2 components are generated by two parallel spinal pathways. Significance: warmth sensation is subserved by parallel spinothalamic pathways, one probably reaching the SII area, the other the ACC
dic-2011
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/39
English
warmth
laser evoked potentials
spinal cord
parallel pathways
C-fibers
Valeriani, M., Pazzaglia, C., Ferraro, D., Virdis, D., Rotellini, S., Le Pera, D., et al. (2011). Evidence of different spinal pathways for the warmth evoked potentials. CLINICAL NEUROPHYSIOLOGY, 122(12), 2469-2474 [10.1016/j.clinph.2011.04.023].
Valeriani, M; Pazzaglia, C; Ferraro, D; Virdis, D; Rotellini, S; Le Pera, D; Testani, E; Minciotti, I; Balestri, M; Vigevano, F; Vollono, C
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S1388245711002811-main.pdf

solo utenti autorizzati

Tipologia: Versione Editoriale (PDF)
Licenza: Copyright dell'editore
Dimensione 370.05 kB
Formato Adobe PDF
370.05 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/367550
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 7
social impact