migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. these changes reflect complex CNS dysfunction patterns. assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. to test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.

de Tommaso, M., Ambrosini, A., Brighina, F., Coppola, G., Perrotta, A., Pierelli, F., et al. (2014). Altered processing of sensory stimuli in patients with migraine. NATURE REVIEWS. NEUROLOGY, 10(3) [10.1038/nrneurol.2014.14].

Altered processing of sensory stimuli in patients with migraine

Massimiliano Valeriani;
2014-01-01

Abstract

migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. these changes reflect complex CNS dysfunction patterns. assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. to test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.
2014
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/39
English
de Tommaso, M., Ambrosini, A., Brighina, F., Coppola, G., Perrotta, A., Pierelli, F., et al. (2014). Altered processing of sensory stimuli in patients with migraine. NATURE REVIEWS. NEUROLOGY, 10(3) [10.1038/nrneurol.2014.14].
de Tommaso, M; Ambrosini, A; Brighina, F; Coppola, G; Perrotta, A; Pierelli, F; Sandrini, G; Valeriani, M; Marinazzo, D; Stramaglia, S; Schoenen, J...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/366705
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